Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
08 Aug 2023
08 Aug 2023
Historique:
received:
17
01
2023
accepted:
27
02
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Serine/threonine-protein kinase B-Raf (BRAF; RAF = rapidly accelerated fibrosarcoma) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade. Somatic mutations in the BRAF gene were first discovered in 2002 by Davies et al., which was a major breakthrough in cancer research. Subsequently, three different classes of BRAF mutants have been discovered. This class includes class I monomeric mutants (BRAF
Identifiants
pubmed: 37576670
doi: 10.1021/acsomega.3c00332
pmc: PMC10413849
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
27819-27844Informations de copyright
© 2023 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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