Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias.
Alzheimer’s disease
brain dynamics
excitatory/inhibitory balance
frontotemporal dementia
resting-state networks
virtual brain modeling
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
04
2023
accepted:
10
07
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Neural circuit alterations lay at the core of brain physiopathology, and yet are hard to unveil in living subjects. The Virtual Brain (TVB) modeling, by exploiting structural and functional magnetic resonance imaging (MRI), yields mesoscopic parameters of connectivity and synaptic transmission. We used TVB to simulate brain networks, which are key for human brain function, in Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients, whose connectivity and synaptic parameters remain largely unknown; we then compared them to healthy controls, to reveal novel The pattern of simulated parameter differed between AD and FTD, shedding light on disease-specific alterations in brain networks. Individual subjects displayed subtle differences in network parameter patterns that significantly correlated with their individual neuropsychological, clinical, and pharmacological profiles. These TVB simulations, by informing about a new personalized set of networks parameters, open new perspectives for understanding dementias mechanisms and design personalized therapeutic approaches.
Identifiants
pubmed: 37577354
doi: 10.3389/fnagi.2023.1204134
pmc: PMC10419271
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1204134Informations de copyright
Copyright © 2023 Monteverdi, Palesi, Schirner, Argentino, Merante, Redolfi, Conca, Mazzocchi, Cappa, Cotta Ramusino, Costa, Pichiecchio, Farina, Jirsa, Ritter, Gandini Wheeler-Kingshott and D’Angelo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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