Dry skin
Proliferative basal cells
scRNA-seq
Journal
Journal of pharmaceutical analysis
ISSN: 2214-0883
Titre abrégé: J Pharm Anal
Pays: China
ID NLM: 101579451
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
08
12
2022
revised:
04
04
2023
accepted:
06
04
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Pathological dry skin is a disturbing and intractable healthcare burden, characterized by epithelial hyperplasia and severe itch. Atopic dermatitis (AD) and psoriasis models with complications of dry skin have been studied using single-cell RNA sequencing (scRNA-seq). However, scRNA-seq analysis of the dry skin mouse model (acetone/ether/water (AEW)-treated model) is still lacking. Here, we used scRNA-seq and in situ hybridization to identify a novel proliferative basal cell (PBC) state that exclusively expresses transcription factor CUT-like homeobox 1 (Cux1). Further in vitro study demonstrated that Cux1 is vital for keratinocyte proliferation by regulating a series of cyclin-dependent kinases (CDKs) and cyclins. Clinically,
Identifiants
pubmed: 37577389
doi: 10.1016/j.jpha.2023.04.004
pii: S2095-1779(23)00065-5
pmc: PMC10422139
doi:
Types de publication
Journal Article
Langues
eng
Pagination
745-759Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
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