A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression.

Drosophila axonal transport dynein force production kinetochore microtubule-binding domain mitosis

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
04 Aug 2023
Historique:
pubmed: 14 8 2023
medline: 14 8 2023
entrez: 14 8 2023
Statut: epublish

Résumé

The cytoplasmic dynein-1 (dynein) motor organizes cells by shaping microtubule networks and moving a large variety of cargoes along them. However, dynein's diverse roles complicate

Identifiants

DOI: 10.1101/2023.08.03.551815 PMID: 37577480 PMC: PMC10418259
pubmed: 37577480
doi: 10.1101/2023.08.03.551815
pmc: PMC10418259
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : Medical Research Council
ID : MC_U105178790
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/N001753/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R35 GM136414
Pays : United States

Déclaration de conflit d'intérêts

CONFLICT OF INTERESTS STATEMENT The authors declare that they have no competing interests.

Auteurs

David Salvador-Garcia (D)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Li Jin (L)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Andrew Hensley (A)

Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.

Mert Gölcük (M)

Department of Mechanical Engineering, Istanbul Technical University, Istanbul, 34437, Turkey.

Emmanuel Gallaud (E)

Institut de Génétique et Développement de Rennes - UMR 6290, Université de Rennes, F-35000 Rennes, France.

Sami Chaaban (S)

Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Fillip Port (F)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Current address: Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Alessio Vagnoni (A)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Current address: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RX, UK.

Vicente José Planelles-Herrero (VJ)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Mark A McClintock (MA)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Emmanuel Derivery (E)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Andrew P Carter (AP)

Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Régis Giet (R)

Institut de Génétique et Développement de Rennes - UMR 6290, Université de Rennes, F-35000 Rennes, France.

Mert Gür (M)

Department of Mechanical Engineering, Istanbul Technical University, Istanbul, 34437, Turkey.
Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Ahmet Yildiz (A)

Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

Simon L Bullock (SL)

Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Classifications MeSH