An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
03 Aug 2023
03 Aug 2023
Historique:
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Systemic Lupus Erythematosus (SLE) is characterized by autoreactive B cell activation, upregulation of Type I Interferon (IFN) and widespread inflammation. Mitochondrial nucleic acids (NAs) are increasingly recognized as triggers of IFN
Identifiants
pubmed: 37577613
doi: 10.1101/2023.08.03.551696
pmc: PMC10418156
pii:
doi:
Types de publication
Preprint
Langues
eng