Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A.
E1A
TRIM35
antiviral
human adenoviruses (HAdV)
ubiquitination
virus–host interactions
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
medline:
1
9
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Human adenovirus (HAdV) is ubiquitous in the human population, constituting a significant burden of global respiratory diseases. Children and individuals with low immunity are at risk of developing severe infections without approved antiviral treatment for HAdV. Our study demonstrated that TRIM35 inhibited HAdV-C5 early gene transcription, early protein expression, genome replication, and infectious virus progeny production. Furthermore, TRIM35 was found to inhibit HAdV replication by attenuating E1A expression. Mechanistically, TRIM35 interacts with and degrades E1A by promoting its K48-linked ubiquitination. Additionally, K253 and K285 are the key sites necessary for TRIM35 degradation. Moreover, an oncolytic adenovirus carrying shTRIM35 was constructed and observed to exhibit improved oncolysis
Identifiants
pubmed: 37578239
doi: 10.1128/jvi.00700-23
pmc: PMC10506487
doi:
Substances chimiques
Adenovirus E1A Proteins
0
Antiviral Agents
0
Apoptosis Regulatory Proteins
0
TRIM35 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0070023Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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