Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).

Humans Drug Discovery Histones / metabolism Neoplasms PR-SET Domains / drug effects

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
24 08 2023
Historique:
medline: 25 8 2023
pubmed: 14 8 2023
entrez: 14 8 2023
Statut: ppublish

Résumé

Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono- or dimethylation of histone 3 lysine 36 (H3K36me1 and H3K36me2), using

Identifiants

DOI: 10.1021/acs.jmedchem.3c00948 PMID: 37578463
pubmed: 37578463
doi: 10.1021/acs.jmedchem.3c00948
doi:

Substances chimiques

Histones 0
NSD2 protein, human EC 2.1.1.43

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

10991-11026

Auteurs

Zonghui Ma (Z)

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.

Andrew A Bolinger (AA)

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.

Haiying Chen (H)

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.

Jia Zhou (J)

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
ORCID: 0000-0002-2811-1090

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Drug Discovery Targeting Nuclear Receptor...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Drug Discovery Targeting Nuclear Receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Drug Discovery Targeting Nuclear Receptor...
questionsmedicales.fr › Tumeurs › Drug Discovery Targeting Nuclear Receptor...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaines PR-SET › Drug Discovery Targeting Nuclear Receptor...