Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications.
Bone regeneration
Denervation
Fracture healing
NGF/TrkA
Peripheral nerve
Skeletal development
Journal
Current osteoporosis reports
ISSN: 1544-2241
Titre abrégé: Curr Osteoporos Rep
Pays: United States
ID NLM: 101176492
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
accepted:
25
07
2023
medline:
4
10
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
This review examines the diverse functional relationships that exist between the peripheral nervous system (PNS) and bone, including key advances over the past century that inform our efforts to translate these discoveries for skeletal repair. The innervation of the bone during development, homeostasis, and regeneration is highly patterned. Consistent with this, there have been nearly 100 studies over the past century that have used denervation approaches to isolate the effects of the different branches of the PNS on the bone. Overall, a common theme of balance emerges whereby an orchestration of both local and systemic neural functions must align to promote optimal skeletal repair while limiting negative consequences such as pain. An improved understanding of the functional bidirectional pathways linking the PNS and bone has important implications for skeletal development and regeneration. Clinical advances over the next century will necessitate a rigorous identification of the mechanisms underlying these effects that is cautious not to oversimplify the in vivo condition in diverse states of health and disease.
Identifiants
pubmed: 37578676
doi: 10.1007/s11914-023-00815-5
pii: 10.1007/s11914-023-00815-5
pmc: PMC10543521
doi:
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
503-518Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027957
Pays : United States
Organisme : NIAMS NIH HHS
ID : R56 AR081251
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32-AR060719
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132073
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01-DK132073
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30-AR074992
Pays : United States
Organisme : NIAMS NIH HHS
ID : R56-AR081251
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01-DE027957
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE032420
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Mol Pain. 2017 Jan-Dec;13:1744806917745465
pubmed: 29166838
FASEB J. 2002 Aug;16(10):1307-9
pubmed: 12154004
J Clin Invest. 2020 Jul 1;130(7):3483-3498
pubmed: 32191640
Acta Orthop. 2010 Oct;81(5):639-46
pubmed: 20860441
Sci Rep. 2020 Dec 17;10(1):22241
pubmed: 33335129
J Musculoskelet Neuronal Interact. 2014 Mar;14(1):1-9
pubmed: 24583535
Biochem Biophys Res Commun. 2020 Oct 22;531(4):559-565
pubmed: 32811642
Clin Orthop Relat Res. 2006 Feb;443:73-4
pubmed: 16462429
J Dent Res. 2021 Sep;100(10):1144-1152
pubmed: 34328037
J Orthop Res. 1991 Nov;9(6):869-75
pubmed: 1919850
EBioMedicine. 2020 Oct;60:103025
pubmed: 32971471
Neuro Oncol. 2022 Oct 3;24(10):1776-1789
pubmed: 35395680
Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16210-5
pubmed: 15520390
Cell Rep. 2016 Sep 6;16(10):2723-2735
pubmed: 27568565
PLoS One. 2014 Aug 21;9(8):e105976
pubmed: 25144690
J Orthop Res. 2023 Jun;41(6):1228-1239
pubmed: 36281531
Cells. 2022 Feb 10;11(4):
pubmed: 35203263
Int J Mol Sci. 2020 Jan 08;21(2):
pubmed: 31936403
J Clin Invest. 2019 Dec 2;129(12):5137-5150
pubmed: 31638597
R Soc Open Sci. 2019 Jan 2;6(1):181082
pubmed: 30800361
J Comp Neurol. 2009 Jul 20;515(3):331-48
pubmed: 19425099
J Orthop Translat. 2017 Mar 27;10:12-17
pubmed: 29662756
Tissue Eng Part A. 2015 Aug;21(15-16):2241-9
pubmed: 25996367
J Bone Miner Res. 2021 May;36(5):1012-1025
pubmed: 33592122
Biomed Res Int. 2020 Aug 16;2020:4503463
pubmed: 32879882
J Comp Neurol. 2020 Jul 15;528(11):1903-1916
pubmed: 31970770
Cell. 2018 Aug 9;174(4):999-1014.e22
pubmed: 30096314
Neuroscience. 2009 Sep 15;162(4):1244-54
pubmed: 19486928
Bone. 2000 Jun;26(6):625-33
pubmed: 10831935
Anat Embryol (Berl). 1990;182(5):493-8
pubmed: 2291494
J Bone Miner Res. 2007 Nov;22(11):1732-42
pubmed: 17638576
J Clin Invest. 2018 Nov 1;128(11):4832-4842
pubmed: 30153111
Int J Med Sci. 2019 Jun 2;16(6):831-837
pubmed: 31337956
J Bone Miner Res. 2022 May;37(5):954-971
pubmed: 35122666
Acta Orthop Scand. 1985 Jun;56(3):233-7
pubmed: 4036573
PLoS One. 2014 Jan 14;9(1):e84845
pubmed: 24454754
Pain. 2014 Nov;155(11):2323-36
pubmed: 25196264
J Orthop. 2019 May 06;16(3):289-292
pubmed: 31193261
Sci Rep. 2019 Mar 29;9(1):5361
pubmed: 30926835
Cell Rep. 2020 May 26;31(8):107696
pubmed: 32460020
J Orthop Res. 2006 Dec;24(12):2238-45
pubmed: 17001706
J Orthop Res. 2007 Sep;25(9):1204-12
pubmed: 17503519
Nat Med. 2016 Oct;22(10):1160-1169
pubmed: 27571347
Clin Orthop Relat Res. 1998 Jun;(351):230-40
pubmed: 9646767
J Bone Miner Res. 2020 May;35(5):932-941
pubmed: 31881108
Artif Cells Blood Substit Immobil Biotechnol. 2009;37(2):85-91
pubmed: 19247856
Curr Osteoporos Rep. 2020 Dec;18(6):621-632
pubmed: 33030684
Cell Physiol Biochem. 2017;41(4):1457-1467
pubmed: 28315869
J Bone Joint Surg Am. 2009 Dec;91(12):2886-95
pubmed: 19952252
J Periodontol. 2010 Sep;81(9):1289-98
pubmed: 20397902
Calcif Tissue Int. 2021 Jul;109(1):55-65
pubmed: 33999216
Ann Oncol. 2019 Nov 1;30(Suppl_8):viii23-viii30
pubmed: 31738426
J Craniomaxillofac Surg. 2019 Mar;47(3):473-483
pubmed: 30616935
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):637-41
pubmed: 25363725
Cell Tissue Res. 1981;217(3):569-76
pubmed: 7249051
J Pain. 2021 Nov;22(11):1385-1395
pubmed: 33964414
J Craniofac Surg. 2012 Sep;23(5):1524-8
pubmed: 22976650
Acta Orthop Scand. 1992 Dec;63(6):579-86
pubmed: 1471500
Neuroscience. 1993 Jun;54(4):969-79
pubmed: 8341427
J Orthop Res. 2015 Aug;33(8):1235-41
pubmed: 25876530
Acta Orthop. 2012 Aug;83(4):406-10
pubmed: 22880710
EBioMedicine. 2020 Sep;59:102970
pubmed: 32853990
Nat Commun. 2022 Jan 27;13(1):535
pubmed: 35087048
Nat Commun. 2021 Aug 16;12(1):4939
pubmed: 34400627
Neuroscience. 2011 Mar 31;178:196-207
pubmed: 21277945
Br J Clin Pharmacol. 2019 Jun;85(6):1103-1113
pubmed: 30357885
Anat Rec. 1995 Oct;243(2):234-40
pubmed: 8554179
Tissue Eng Part A. 2011 Apr;17(7-8):955-67
pubmed: 21091323
Adv Sci (Weinh). 2022 Jan;9(1):e2103005
pubmed: 34708571
Tissue Eng. 2005 Sep-Oct;11(9-10):1618-29
pubmed: 16259615
Am J Physiol Cell Physiol. 2010 Dec;299(6):C1485-92
pubmed: 20881236
Curr Osteoporos Rep. 2018 Aug;16(4):325-332
pubmed: 29948820
Cancer Cell. 2017 Mar 13;31(3):342-354
pubmed: 28292437
Neuroscience. 1991;44(3):747-55
pubmed: 1721689
Stem Cell Res Ther. 2021 Jul 7;12(1):382
pubmed: 34233721
Acta Med Okayama. 2006 Oct;60(5):267-77
pubmed: 17072373
Ann N Y Acad Sci. 2019 Jul;1448(1):52-64
pubmed: 31095746
Sci Rep. 2023 Mar 22;13(1):4674
pubmed: 36949102
J Bone Miner Res. 2019 Aug;34(8):1393-1406
pubmed: 31247122
Open Biol. 2020 Sep;10(9):200194
pubmed: 32993414
Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):
pubmed: 29500307
Pain. 2017 Apr;158(4):543-559
pubmed: 28301400
Biochim Biophys Acta. 2016 Aug;1866(1):37-50
pubmed: 27264679
Front Physiol. 2016 Apr 26;7:157
pubmed: 27199772
J Bone Miner Res. 2023 Jan;38(1):119-130
pubmed: 36331097
J Musculoskelet Neuronal Interact. 2022 Dec 1;22(4):524-535
pubmed: 36458390
Sci Adv. 2022 Mar 18;8(11):eabl5716
pubmed: 35302859
Bone. 2003 Nov;33(5):788-97
pubmed: 14623054
J Orthop Surg Res. 2021 Jan 21;16(1):74
pubmed: 33478541
Essays Biochem. 1998;33:1-13
pubmed: 10488437
JBMR Plus. 2020 Jul 30;4(9):e10388
pubmed: 32995691
Cell. 2002 Nov 1;111(3):305-17
pubmed: 12419242
Anesth Analg. 2020 Feb;130(2):498-504
pubmed: 30985383
J Bone Miner Res. 2001 Aug;16(8):1505-10
pubmed: 11499873
Dev Biol. 2019 Jan 15;445(2):237-244
pubmed: 30458171
J Orthop Res. 1997 Mar;15(2):235-42
pubmed: 9167626
Auton Neurosci. 2013 Oct;177(2):237-43
pubmed: 23769156
Bone. 1999 Nov;25(5):545-51
pubmed: 10574574
Biomaterials. 2021 Jan;268:120535
pubmed: 33271450
Adv Sci (Weinh). 2021 Feb 10;8(7):2003390
pubmed: 33854888
Nat Neurosci. 2015 Jan;18(1):145-53
pubmed: 25420068
Nat Commun. 2019 Jan 14;10(1):181
pubmed: 30643142
JAMA. 2004 Sep 15;292(11):1326-32
pubmed: 15367554
Biomed Mater. 2010 Oct;5(5):055002
pubmed: 20826910
Development. 2016 Aug 1;143(15):2724-31
pubmed: 27317805
Bone. 2023 Jan;166:116596
pubmed: 36307018
J Orthop Sci. 2015 Nov;20(6):1114-21
pubmed: 26362654
Ann Surg. 1917 Aug;66(2):201-7
pubmed: 17863764
Dev Biol. 2022 Jun;486:71-80
pubmed: 35353991
eNeuro. 2018 Sep 13;5(5):
pubmed: 30221190
J Bone Miner Res. 2005 Feb;20(2):257-67
pubmed: 15647820
J Clin Invest. 2019 Mar 1;129(3):1076-1093
pubmed: 30530994
J Trauma. 1977 May;17(5):355-61
pubmed: 859187
Reg Anesth Pain Med. 2021 Dec;46(12):1080-1084
pubmed: 34686579
J Biomed Mater Res B Appl Biomater. 2018 May;106(4):1611-1617
pubmed: 28834247
Eur J Pain. 2012 Aug;16(7):953-65
pubmed: 22337615
Bone. 2010 Jun;46(6):1591-6
pubmed: 20193788
Sci Rep. 2023 Feb 6;13(1):2097
pubmed: 36747028
J Mol Histol. 2016 Dec;47(6):579-586
pubmed: 27681986
Biomed Res Int. 2014;2014:412570
pubmed: 25101279
Br J Oral Maxillofac Surg. 2010 Oct;48(7):515-9
pubmed: 20236741
Innov Clin Neurosci. 2020 Apr 1;17(4-6):39-40
pubmed: 32802591
Arch Oral Biol. 2021 Nov;131:105252
pubmed: 34500260
Cell Stem Cell. 2016 Oct 6;19(4):433-448
pubmed: 27376984
J Musculoskelet Neuronal Interact. 2019 Mar 1;19(1):94-103
pubmed: 30839307
Development. 2014 May;141(9):1875-83
pubmed: 24700820
Stem Cells Dev. 2020 May 15;29(10):655-666
pubmed: 32070222
Tissue Eng Part A. 2019 Aug;25(15-16):1072-1083
pubmed: 30489221