Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus.
Antimicrobial resistance
ForM
Fosfomycin
Mycobacterium abscessus
Journal
Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
Titre abrégé: Biochim Biophys Acta Gen Subj
Pays: Netherlands
ID NLM: 101731726
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
20
07
2023
revised:
09
08
2023
accepted:
10
08
2023
medline:
18
9
2023
pubmed:
15
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitors for the enzyme FosB from Staphylococcus aureus. We have tested those same compounds for inhibition of FosM, the fosfomycin-modifying enzyme from M. abscessus. The work described here will be used as the basis for more detailed studies into the inhibition of FosM.
Identifiants
pubmed: 37579984
pii: S0304-4165(23)00142-3
doi: 10.1016/j.bbagen.2023.130444
pii:
doi:
Substances chimiques
Fosfomycin
2N81MY12TE
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
130444Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM148956
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest There are no conflicts of interest to declare.