Long-term control of lung metastasis of tongue cancer treated effectively with cetuximab combination chemotherapy.
Humans
Male
Middle Aged
Tongue Neoplasms
/ diagnostic imaging
Cetuximab
/ therapeutic use
Carcinoma, Squamous Cell
/ diagnostic imaging
Mouth Neoplasms
/ pathology
Neoplasm Staging
Lymphatic Metastasis
Neck Dissection
/ methods
Lung Neoplasms
/ diagnostic imaging
Drug Therapy, Combination
Head and Neck Neoplasms
/ surgery
Neoplasm Recurrence, Local
/ pathology
Cetuximab
Head and neck squamous cell carcinoma
Neoplasm metastasis
Oral squamous cell carcinoma
Tongue cancer
Journal
International journal of oral and maxillofacial surgery
ISSN: 1399-0020
Titre abrégé: Int J Oral Maxillofac Surg
Pays: Denmark
ID NLM: 8605826
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
05
03
2023
revised:
30
06
2023
accepted:
11
07
2023
medline:
20
11
2023
pubmed:
15
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Generally, systemic chemotherapy is indicated for oral squamous cell carcinoma with distant metastasis and has a poor prognosis. Recently, the advent of molecular targeted drugs, such as cetuximab and immune checkpoint inhibitors, has dramatically improved prognosis, though controlling distant metastasis remains challenging. We report a case of tongue cancer in which lung metastases disappeared in the long term. A 60-year-old Japanese male with squamous cell carcinoma of the tongue underwent preoperative chemoradiotherapy and surgery including subtotal glossectomy, bilateral modified radical neck dissection, and immediate reconstruction with an anterolateral thigh flap. One month after surgery, multiple nodules less than 10 mm in diameter appeared in both lungs on CT imaging. Multiple lung metastases were diagnosed with no local recurrence or regional lymph node metastasis. The patient continues to receive a 4-week treatment course of chemotherapy that included cetuximab every 3 months and the lung metastases were markedly reduced in size or had disappeared. No local recurrence or newly emerged metastases were observed. The patient has been doing well for nine years since the appearance of the lung metastases.
Identifiants
pubmed: 37580187
pii: S0901-5027(23)00162-5
doi: 10.1016/j.ijom.2023.07.001
pii:
doi:
Substances chimiques
Cetuximab
PQX0D8J21J
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1221-1224Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Competing interests None.