Food allergen sensitization on a chip: the gut-immune-skin axis.
food allergen sensitization
gut–immune–skin axis
microfluidics
organ-on-a-chip technologies
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
12 Aug 2023
12 Aug 2023
Historique:
received:
17
05
2023
revised:
21
07
2023
accepted:
24
07
2023
medline:
15
8
2023
pubmed:
15
8
2023
entrez:
14
8
2023
Statut:
aheadofprint
Résumé
The global population is growing, rapidly increasing the demand for sustainable, novel, and safe food proteins with minimal risks of food allergy. In vitro testing of allergy-sensitizing capacity is predominantly based on 2D assays. However, these lack the 3D environment and crosstalk between the gut, skin, and immune cells essential for allergy prediction. Organ-on-a-chip (OoC) technologies are promising to study type 2 immune activation required for sensitization, initiated in the small intestine or skin, in interlinked systems. Increasing the mechanistic understanding and, moreover, finding new strategies to study interorgan communication is of importance to recapitulate food allergen sensitization in vitro. Here, we outline recently developed OoC platforms and discuss the features needed for reliable prediction of sensitizing allergenicity of proteins.
Identifiants
pubmed: 37580191
pii: S0167-7799(23)00214-7
doi: 10.1016/j.tibtech.2023.07.005
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests J.G. is head of the Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science at Utrecht University and partly employed by Danone Nutricia Research B.V. The remaining authors declare no competing interests.