Biomonitoring of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from the Survey of the Health of Wisconsin (SHOW) 2014-2016 and comparison with the National Health and Nutrition Examination Survey (NHANES).
Exposure assessment
PFAS
Per and Poly fluoroalkyl substances
Population-based
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
09
04
2023
accepted:
01
08
2023
revised:
27
07
2023
medline:
2
10
2023
pubmed:
15
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Per- and polyfluoroalkyl substances (PFAS) are a growing class of manufactured chemical compounds found in a variety of consumer products. PFAS are ubiquitous in the environment and were found in many humans sampled in the United States (U.S.). Yet, significant gaps in understanding statewide levels of exposure to PFAS remain. The goals of this study are to establish a baseline of exposure at the state level by measuring PFAS serum levels among a representative sample of Wisconsin residents and compare to United States National Health and Nutrition Examination Survey (NHANES). The study sample included 605 adults (18+ years of age) selected from the 2014-2016 sample of the Survey of the Health of Wisconsin (SHOW). Thirty-eight PFAS serum concentrations were measured using high-pressure liquid chromatography coupled with tandem mass spectrometric detection (HPLC-MS/MS) and geometric means were presented. Weighted geometric mean serum values of eight PFAS analytes from SHOW were compared to U.S. national levels from the NHANES 2015-2016 sample (PFOS, PFOA, PFNA, PFHxS, PFHpS, PFDA, PFUnDA), and the 2017-2018 sample for Me-PFOSA, PFHPS using the Wilcoxon rank-sum test. PFOS, PFHxS, PFHpS, PFDA, PFNA, and PFOA were detected in over 96% of SHOW participants. In general, SHOW participants had lower serum levels across all PFAS when compared to NHANES. Serum levels increased with age and were higher among males and whites. Similar trends were seen in NHANES, except non-whites had higher PFAS levels at higher percentiles in NHANES. The present study conducts biomonitoring of 38 PFAS among representative sample of residents in the state of Wisconsin. Results suggest that while the majority of Wisconsin residents tested have detectable levels of PFAS in their blood serum, they may have a lower body burden of some PFAS compared to a nationally representative sample. Older adults, males, and whites may have a higher body burden of PFAS relative to other groups, both in Wisconsin and the wider United States.
Sections du résumé
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) are a growing class of manufactured chemical compounds found in a variety of consumer products. PFAS are ubiquitous in the environment and were found in many humans sampled in the United States (U.S.). Yet, significant gaps in understanding statewide levels of exposure to PFAS remain.
OBJECTIVE
The goals of this study are to establish a baseline of exposure at the state level by measuring PFAS serum levels among a representative sample of Wisconsin residents and compare to United States National Health and Nutrition Examination Survey (NHANES).
METHODS
The study sample included 605 adults (18+ years of age) selected from the 2014-2016 sample of the Survey of the Health of Wisconsin (SHOW). Thirty-eight PFAS serum concentrations were measured using high-pressure liquid chromatography coupled with tandem mass spectrometric detection (HPLC-MS/MS) and geometric means were presented. Weighted geometric mean serum values of eight PFAS analytes from SHOW were compared to U.S. national levels from the NHANES 2015-2016 sample (PFOS, PFOA, PFNA, PFHxS, PFHpS, PFDA, PFUnDA), and the 2017-2018 sample for Me-PFOSA, PFHPS using the Wilcoxon rank-sum test.
RESULTS
PFOS, PFHxS, PFHpS, PFDA, PFNA, and PFOA were detected in over 96% of SHOW participants. In general, SHOW participants had lower serum levels across all PFAS when compared to NHANES. Serum levels increased with age and were higher among males and whites. Similar trends were seen in NHANES, except non-whites had higher PFAS levels at higher percentiles in NHANES.
IMPACT STATEMENT
The present study conducts biomonitoring of 38 PFAS among representative sample of residents in the state of Wisconsin. Results suggest that while the majority of Wisconsin residents tested have detectable levels of PFAS in their blood serum, they may have a lower body burden of some PFAS compared to a nationally representative sample. Older adults, males, and whites may have a higher body burden of PFAS relative to other groups, both in Wisconsin and the wider United States.
Identifiants
pubmed: 37580384
doi: 10.1038/s41370-023-00593-3
pii: 10.1038/s41370-023-00593-3
doi:
Substances chimiques
Fluorocarbons
0
Environmental Pollutants
0
Alkanesulfonic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
766-777Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR025011
Pays : United States
Organisme : NHLBI NIH HHS
ID : RC2 HL101468
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD047873
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
Ghisi R, Vamerali T, Manzetti S. Accumulation of perfluorinated alkyl substances (PFAS) in agricultural plants: a review. Environ Res. 2019;169:326–41.
doi: 10.1016/j.envres.2018.10.023
pubmed: 30502744
Sunderland EM, Hu XC, Dassuncao C, Tokranov AK, Wagner CC, Allen JG. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (pfass) and present understanding of health effects. J Exposure Sci Environ Epidemiol. 2018;29:131–47.
doi: 10.1038/s41370-018-0094-1
Panieri E, Baralic K, Djukic-Cosic D, Buha Djordjevic A, Saso L. PFAS molecules: a major concern for the human health and the environment. Toxics. 2022;10:44.
doi: 10.3390/toxics10020044
pubmed: 35202231
pmcid: 8878656
Haukås M, Berger U, Hop H, Gulliksen B, Gabrielsen GW. Bioaccumulation of per- and polyfluorinated alkyl substances (PFAS) in selected species from the Barents Sea Food web. Environ Pollut. 2007;148:360–71.
doi: 10.1016/j.envpol.2006.09.021
pubmed: 17258363
Per- and polyfluorinated substances (PFAS) factsheet [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; 2022. Available from: https://www.cdc.gov/biomonitoring/PFAS_FactSheet.html .
Hu XC, Andrews DQ, Lindstrom AB, Bruton TA, Schaider LA, Grandjean P, et al. Detection of poly- and perfluoroalkyl substances (pfass) in U.S. drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants. Environ Sci Technol Lett. 2016;3:344–50.
doi: 10.1021/acs.estlett.6b00260
pubmed: 27752509
pmcid: 5062567
Faithfull NS, Weers JG. Perfluorocarbon compounds. Vox Sanguinis. 1998;74:243–8.
doi: 10.1111/j.1423-0410.1998.tb05426.x
pubmed: 9704451
Sinclair GM, Long SM, Jones OAH. What are the effects of PFAS exposure at environmentally relevant concentrations? Chemosphere 2020;258:127340.
doi: 10.1016/j.chemosphere.2020.127340
pubmed: 32563917
Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, et al. Per‐ and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research. Environ Toxicol Chem. 2020;40:606–30.
doi: 10.1002/etc.4890
pubmed: 33017053
pmcid: 7906952
Kurwadkar S, Dane J, Kanel SR, Nadagouda MN, Cawdrey RW, Ambade B, et al. Per- and polyfluoroalkyl substances in water and wastewater: a critical review of their global occurrence and distribution. Sci Total Environ. 2022;809:151003.
doi: 10.1016/j.scitotenv.2021.151003
pubmed: 34695467
DeWitt JC. Toxicological effects of perfluoroalkyl and polyfluoroalkyl substances. Cham, New York: Springer International Publishing; 2015.
Nelson JW, Hatch EE, Webster TF. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environ Health Perspect. 2010;118:197–202.
doi: 10.1289/ehp.0901165
pubmed: 20123614
Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, et al. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut. 2019;247:1055–63.
doi: 10.1016/j.envpol.2019.01.064
pubmed: 30823334
pmcid: 6404528
Wikström S, Lin P-I, Lindh CH, Shu H, Bornehag C-G. Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight. Pediatr Res. 2019;87:1093–9.
doi: 10.1038/s41390-019-0720-1
pubmed: 31835271
pmcid: 7196936
von Holst H, Nayak P, Dembek Z, Buehler S, Echeverria D, Fallacara D, et al. Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies. Heliyon. 2021;7:e08160.
doi: 10.1016/j.heliyon.2021.e08160
Borghese MM, Walker M, Helewa ME, Fraser WD, Arbuckle TE. Association of perfluoroalkyl substances with gestational hypertension and preeclampsia in the MIREC study. Environ Int. 2020;141:105789.
doi: 10.1016/j.envint.2020.105789
pubmed: 32408216
Granum B, Haug LS, Namork E, Stølevik SB, Thomsen C, Aaberge IS, et al. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J Immunotoxicol. 2013;10:373–9.
doi: 10.3109/1547691X.2012.755580
pubmed: 23350954
Brennan NM, Evans AT, Fritz MK, Peak SA, von Holst HE. Trends in the regulation of per- and polyfluoroalkyl substances (PFAS): a scoping review. Int J Environ Res Public Health. 2021;18:10900.
doi: 10.3390/ijerph182010900
pubmed: 34682663
pmcid: 8536021
Chen J, Tang L, Chen W-Q, Peaslee GF, Jiang D. Flows, stock, and emissions of poly- and perfluoroalkyl substances in California carpet in 2000–2030 under different scenarios. Environ Sci Technol. 2020;54:6908–18.
doi: 10.1021/acs.est.9b06956
pubmed: 32352763
Podder A, Sadmani AHMA, Reinhart D, Chang N-B, Goel R. Per and poly-fluoroalkyl substances (PFAS) as a contaminant of emerging concern in Surface Water: a transboundary review of their occurrences and toxicity effects. J Hazard Mater. 2021;419:126361.
doi: 10.1016/j.jhazmat.2021.126361
pubmed: 34157464
US EPA. Lifetime Drinking Water Health Advisories for Four Perfluoroalkyl Substances. 2022; 87 FRL 9855–01–OW. (To be codified and 87 C.F.R. pts. 36848, 36849).
Kidd J, Fabricatore E, Jackson D. Current and future federal and state sampling guidance for per- and polyfluoroalkyl substances in environmental matrices. Sci Total Environ. 2022;836:155523.
doi: 10.1016/j.scitotenv.2022.155523
pubmed: 35504374
Chang CJ, Ryan PB, Smarr MM, Kannan K, Panuwet P, Dunlop A, et al. Serum per-and polyfluoroalkyl substance (PFAS) concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia. Environ Res. 2021;157:106843. Available from: https://www.sciencedirect.com/science/article/pii/S0160412021004682?via%3Dihub .
Birnbaum LS, Grandjean P. Alternatives to pfass: perspectives on the science. Environ Health Perspect. 2015;123:A104–5.
doi: 10.1289/ehp.1509944
pubmed: 25932670
pmcid: 4421778
Aylward LL, Seiber JN, Hays SM. California biomonitoring data: comparison to NHANES and interpretation in a risk assessment context. Regulatory Toxicol Pharmacol. 2015;73:875–84.
doi: 10.1016/j.yrtph.2015.10.002
Graber JM, Alexander C, Laumbach RJ, Black K, Strickland PO, Georgopoulos PG, et al. Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES. J Exposure Sci Environ Epidemiol. 2018;29:172–82.
doi: 10.1038/s41370-018-0096-z
Graber JM, Black TM, Shah NN, Caban-Martinez AJ, Lu SE, Brancard T, et al. Prevalence and predictors of per- and polyfluoroalkyl substances (PFAS) serum levels among members of a suburban US volunteer fire department. Int J Environ Res Public Health. 2021;18:3730.
doi: 10.3390/ijerph18073730
pubmed: 33918459
pmcid: 8038206
Petriello MC, Mottaleb MA, Serio TC, Balyan B, Cave MC, Pavuk M, et al. Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II). Environ Int. 2022;158:106907.
doi: 10.1016/j.envint.2021.106907
pubmed: 34763231
Yu CH, Weisel CP, Alimokhtari S, Georgopoulos PG, Fan ZT. Biomonitoring: a tool to assess PFNA body burdens and evaluate the effectiveness of drinking water intervention for communities in New Jersey. Int J Hyg Environ Health. 2021;235:113757.
doi: 10.1016/j.ijheh.2021.113757
pubmed: 33962122
Multiple state agencies responding to PFAS contamination on French Island [Internet]. Wisconsin Department of Natural Resources. Wisconsin Department of Natural Resources; 2021. Available from: https://dnr.wisconsin.gov/newsroom/release/42441 .
Pfas contamination in the Marinette and Peshtigo Area [Internet]. PFAS Contamination in the Marinette and Peshtigo Area | | Wisconsin DNR. Wisconsin Department of Natural Resources; 2022. Available from: https://dnr.wisconsin.gov/topic/PFAS/Marinette.html .
Jha G, Kankarla V, McLennon E, Pal S, Sihi D, Dari B, et al. Per- and polyfluoroalkyl substances (PFAS) in integrated crop–livestock systems: environmental exposure and human health risks. Int J Environ Res Public Health. 2021;18:12550.
doi: 10.3390/ijerph182312550
pubmed: 34886275
pmcid: 8657007
Johnson GR. Pfas in soil and groundwater following historical land application of Biosolids. Water Res. 2022;211:118035.
doi: 10.1016/j.watres.2021.118035
pubmed: 35032876
Water utility [Internet]. City of Madison, Wisconsin. Available from: https://www.cityofmadison.com/water/water-quality/water-quality-testing/perfluorinated-compounds .
Staff AC. Wisconsin population increased 3.6% since 2010 [Internet]. Census.gov. United States Census Bureau; 2021. Available from: https://www.census.gov/library/stories/state-by-state/wisconsin-population-change-between-census-decade.html .
Malecki KM, Nikodemova M, Schultz AA, LeCaire TJ, Bersch AJ, Cadmus-Bertram L, et al. The survey of the Health of Wisconsin (show) program: an infrastructure for advancing population health. Front Public Health. 2022;10:818777.
doi: 10.3389/fpubh.2022.818777
pubmed: 35433595
pmcid: 9008403
Minnesota Dept. of Public Health, Public Health Laboratory Division. Document DOC-563, Detection of PFAS in serum and Plasma via LC-MS/MS. Unpublished methods.
Centers for Disease Control & Prevention, National Center for Environmental Health. Laboratory Procedure manual NHANES 2015-16, method 6304.08. Perfluoroalkyl and Polyfluoroalkyl Substances.
New York State Dept. of Health, Division of Environmental Health Sciences, Laboratory of Organic Analytical Chemistry. Analysis of Perfluoroalkyl Substances In Human Serum by Solid Phase Extraction and Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. Unpublished methods.
Michigan Dept. of Community Health, Bureau of Laboratories. Document AC-54. Analysis of serum for PFAS by RP-HPLC-MRM-MS/MS. 2018. Unpublished methods.
Centers for Disease Control and Prevention. Nhanes - about the National Health and Nutrition Examination Survey. 2017. https://www.cdc.gov/nchs/nhanes/about_nhanes.htm (accessed 2 May 2022).
Prior HHS Poverty Guidelines and Federal Register references [Internet]. ASPE. 2022. Available from: https://aspe.hhs.gov/topics/poverty-economic-mobility/poverty-guidelines/prior-hhs-poverty-guidelines-federal-register-references .
Yu CH, Riker CD, Lu SE, Fan ZT. Biomonitoring of emerging contaminants, perfluoroalkyl and polyfluoroalkyl substances (PFAS), in New Jersey Adults in 2016–2018. Int J Hyg Environ Health. 2020;223:34–44.
doi: 10.1016/j.ijheh.2019.10.008
pubmed: 31679856
Brunn H, Arnold G, Körner W, Rippen G, Steinhäuser KG, Valentin I. PFAS: forever chemicals—persistent, bioaccumulative and mobile. Reviewing the status and the need for their phase out and remediation of contaminated sites. Environ Sci Eur. 2023;35:1–50.
Yao Y, Burgess J, Volchek K, Brown C. Short-Chain PFAS Their Sources, Properties, Toxicity, Environmental Fate, and Treatment. In: Kempisty D, Xing Y, Racz L, editors. Perfluoroalkyl Substances in the Environment Theory, Practice, and Innovation [Internet]. Boca Raton: CRC Press; 2018. p. 447–67. Available from: https://www.taylorfrancis.com/chapters/edit/10.1201/9780429487125-20/short-chain-pfas-yuan-yao-justin-burgess-konstantin-volchek-carl-brown?context=ubx&refId=afa9c083-21ea-4dae-9c6e-4050e54eb255 .
Nair AS, Ma ZQ, Watkins SM, Wood SS. Demographic and exposure characteristics as predictors of serum per- and polyfluoroalkyl substances (pfass) levels – a community-level biomonitoring project in Pennsylvania. Int J Hyg Environ Health. 2021;231:113631.
doi: 10.1016/j.ijheh.2020.113631
pubmed: 33035738
Sagiv SK, Rifas-Shiman SL, Webster TF, Mora AM, Harris MH, Calafat AM, et al. Sociodemographic and perinatal predictors of early pregnancy per- and polyfluoroalkyl substance (PFAS) concentrations. Environ Sci Technol. 2015;49:11849–58.
doi: 10.1021/acs.est.5b02489
pubmed: 26333069
pmcid: 4638415
Wattigney WA, Savadatti SS, Liu M, Pavuk M, Lewis-Michl E, Kannan K, et al. Biomonitoring of per- and polyfluoroalkyl substances in minority angler communities in Central New York State. Environ Res. 2022;204:112309.
doi: 10.1016/j.envres.2021.112309
pubmed: 34728236
Olsen GW, Mair DC, Lange CC, Harrington LM, Church TR, Goldberg CL, et al. Per- and polyfluoroalkyl substances (PFAS) in American Red Cross Adult Blood Donors, 2000–2015. Environ Res. 2017;157:87–95.
doi: 10.1016/j.envres.2017.05.013
pubmed: 28528142
Ding N, Harlow SD, Batterman S, Mukherjee B, Park SK. Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The study of women′s health across the nation. Environ Int. 2020;135:105381.
doi: 10.1016/j.envint.2019.105381
pubmed: 31841808
DeLuca, NM, Thomas, K, Mullikin, A, Slover, R, Stanek, LW, Pilant, AN, et al. Geographic and demographic variability in serum PFAS concentrations for pregnant women in the United States. J Exp Sci Environ Epidemiol. 2023:1–15. PMID: 36697764 https://doi.org/10.1038/s41370-023-00520-6 .
Chang CJ, Ryan PB, Smarr MM, Kannan K, Panuwet P, Dunlop AL, et al. Serum per-and polyfluoroalkyl substance (PFAS) concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia. Environ Res. 2021;198:110445.
doi: 10.1016/j.envres.2020.110445
pubmed: 33186575
Evans GW, Kantrowitz E. Socioeconomic status and health: The potential role of environmental risk exposure. Annu Rev Public Health. 2002;23:303–31.