Balancing lysosome abundance in health and disease.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
05
02
2023
accepted:
28
06
2023
medline:
13
9
2023
pubmed:
15
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.
Identifiants
pubmed: 37580388
doi: 10.1038/s41556-023-01197-7
pii: 10.1038/s41556-023-01197-7
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1254-1264Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM051405
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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