Variability of visual field maps in human early extrastriate cortex challenges the canonical model of organization of V2 and V3.
Human Connectome Project
V3
hemispheric differences
high-resolution fMRI
human
interindividual variability
neuroscience
retinotopy
vision
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 08 2023
15 08 2023
Historique:
received:
26
01
2023
accepted:
02
08
2023
medline:
16
8
2023
pubmed:
15
8
2023
entrez:
15
8
2023
Statut:
epublish
Résumé
Visual field maps in human early extrastriate areas (V2 and V3) are traditionally thought to form mirror-image representations which surround the primary visual cortex (V1). According to this scheme, V2 and V3 form nearly symmetrical halves with respect to the calcarine sulcus, with the dorsal halves representing lower contralateral quadrants, and the ventral halves representing upper contralateral quadrants. This arrangement is considered to be consistent across individuals, and thus predictable with reasonable accuracy using templates. However, data that deviate from this expected pattern have been observed, but mainly treated as artifactual. Here, we systematically investigate individual variability in the visual field maps of human early visual cortex using the 7T Human Connectome Project (HCP) retinotopy dataset. Our results demonstrate substantial and principled inter-individual variability. Visual field representation in the dorsal portions of V2 and V3 was more variable than in their ventral counterparts, including substantial departures from the expected mirror-symmetrical patterns. In addition, left hemisphere retinotopic maps were more variable than those in the right hemisphere. Surprisingly, only one-third of individuals had maps that conformed to the expected pattern in the left hemisphere. Visual field sign analysis further revealed that in many individuals the area conventionally identified as dorsal V3 shows a discontinuity in the mirror-image representation of the retina, associated with a Y-shaped lower vertical representation. Our findings challenge the current view that inter-individual variability in early extrastriate cortex is negligible, and that the dorsal portions of V2 and V3 are roughly mirror images of their ventral counterparts.
Identifiants
pubmed: 37580963
doi: 10.7554/eLife.86439
pii: 86439
pmc: PMC10427147
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Informations de copyright
© 2023, Ribeiro et al.
Déclaration de conflit d'intérêts
FR, AY, EZ, SB, MR, AP No competing interests declared
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