Mechanistic Study on the Degradation of Hydrolysable Core-Crosslinked Polymeric Micelles.


Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
29 08 2023
Historique:
medline: 31 8 2023
pubmed: 15 8 2023
entrez: 15 8 2023
Statut: ppublish

Résumé

Core-crosslinked polymeric micelles (CCPMs) are an attractive class of nanocarriers for drug delivery. Two crosslinking approaches to form CCPMs exist: either via a low-molecular-weight crosslinking agent to connect homogeneous polymer chains with reactive handles or via cross-reactive handles on polymers to link them to each other (complementary polymers). Previously, CCPMs based on methoxy poly(ethylene glycol)-

Identifiants

pubmed: 37581242
doi: 10.1021/acs.langmuir.3c01399
pmc: PMC10469444
doi:

Substances chimiques

Micelles 0
Cysteine K848JZ4886
Polymers 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12132-12143

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Auteurs

Erik R Hebels (ER)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Mies J van Steenbergen (MJ)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Ragna Haegebaert (R)

Laboratory for General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium.

Cornelis W Seinen (CW)

Division Laboratories, Pharmacy and Biomedical Genetics, Central Diagnostic Lab, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Barbara S Mesquita (BS)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Antoinette van den Dikkenberg (A)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Katrien Remaut (K)

Laboratory for General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium.

Cristianne J F Rijcken (CJF)

Cristal Therapeutics, 6229 EV Maastricht, The Netherlands.

Bas G P van Ravensteijn (BGP)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Wim E Hennink (WE)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

Tina Vermonden (T)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3508 TB Utrecht, The Netherlands.

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Classifications MeSH