Semenogelins Armed in Zn(II) and Cu(II): May Bioinorganic Chemistry Help Nature to Cope with


Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
28 Aug 2023
Historique:
medline: 29 8 2023
pubmed: 15 8 2023
entrez: 15 8 2023
Statut: ppublish

Résumé

Proteolytic degradation of semenogelins, the most abundant proteins from human semen, results in the formation of 26- and 29-amino acid peptides (SgIIA and SgI-29, respectively), which share a common 15 amino acid fragment (Sg-15). All three ligands are effective Zn(II) and Cu(II) binders; in solution, a variety of differently metalated species exist in equilibrium, with the [NH

Identifiants

pubmed: 37582221
doi: 10.1021/acs.inorgchem.3c02390
pmc: PMC10466376
doi:

Substances chimiques

Copper 789U1901C5
Anti-Infective Agents 0
Zinc J41CSQ7QDS

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14103-14115

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Auteurs

Dorota Dudek (D)

Faculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.

Adriana Miller (A)

Faculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.

Aleksandra Hecel (A)

Faculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.

Arian Kola (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.

Daniela Valensin (D)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.

Aleksandra Mikołajczyk (A)

Screening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wrocław Medical University, 50-556 Wroclaw, Poland.

Miquel Barcelo-Oliver (M)

Department of Chemistry, University of Balearic Islands, 07122 Palma de Mallorca, Spain.

Agnieszka Matera-Witkiewicz (A)

Screening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wrocław Medical University, 50-556 Wroclaw, Poland.

Magdalena Rowińska-Żyrek (M)

Faculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.

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Classifications MeSH