Behavioral measurements of motor readiness in mice.
delayed response task
dynamic motor planning
licking
mice
motor behavior
motor planning
reaching
uncertainty
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
11 09 2023
11 09 2023
Historique:
received:
26
02
2023
revised:
09
05
2023
accepted:
18
07
2023
pmc-release:
11
09
2024
medline:
14
9
2023
pubmed:
16
8
2023
entrez:
15
8
2023
Statut:
ppublish
Résumé
Motor planning facilitates rapid and precise execution of volitional movements. Although motor planning has been classically studied in humans and monkeys, the mouse has become an increasingly popular model system to study neural mechanisms of motor planning. It remains yet untested whether mice and primates share common behavioral features of motor planning. We combined videography and a delayed response task paradigm in an autonomous behavioral system to measure motor planning in non-body-restrained mice. Motor planning resulted in both reaction time (RT) savings and increased movement accuracy, replicating classic effects in primates. We found that motor planning was reflected in task-relevant body features. Both the specific actions prepared and the degree of motor readiness could be read out online during motor planning. The online readout further revealed behavioral evidence of simultaneous preparation for multiple actions under uncertain conditions. These results validate the mouse as a model to study motor planning, demonstrate body feature movements as a powerful real-time readout of motor readiness, and offer behavioral evidence that motor planning can be a parallel process that permits rapid selection of multiple prepared actions.
Identifiants
pubmed: 37582373
pii: S0960-9822(23)00967-3
doi: 10.1016/j.cub.2023.07.029
pmc: PMC10529875
mid: NIHMS1921120
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3610-3624.e4Subventions
Organisme : NINDS NIH HHS
ID : R01 NS112312
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS113110
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS104781
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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