Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway.

Humans Adipogenesis AMP-Activated Protein Kinases / metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics Diabetes Mellitus, Type 2 / metabolism Adipose Tissue, White / metabolism Signal Transduction Coenzyme A / metabolism
ACAT1 AMPK Brown adipocytes PGC1α Palmitoylation

Journal

Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727

Informations de publication

Date de publication:
10 2023
Historique:
received: 12 02 2023
revised: 08 07 2023
accepted: 19 07 2023
medline: 8 9 2023
pubmed: 16 8 2023
entrez: 15 8 2023
Statut: ppublish

Résumé

Brown adipose tissue (BAT) is thermogenic, expressing high levels of uncoupling protein-1 to convert nutrient energy to heat energy, bypassing ATP synthesis. BAT is a promising therapeutic target for treatment of obesity and type 2 diabetes since it converts fatty acids into heat but mechanisms controlling brown adipogenesis remain unclear. Knockdown of acetyl-Coenzyme A acetyltransferase 1 (ACAT1) in C3H10T1/2 cells suppressed brown adipocyte maturation during the current study and ACAT1 overexpression promoted brown adipocyte maturation. The downstream target of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator-1-α (PGC1α), was involved in the action of ACAT1 on brown adipocyte maturation. ACAT1 overexpression enhanced AMPK phosphorylation and promoted PGC1α expression. It is suggested that ACAT1 promotes brown adipocyte maturation by activating the AMPK-PGC1α signaling pathway.

Identifiants

DOI: 10.1016/j.bbalip.2023.159369 PMID: 37582428
pubmed: 37582428
pii: S1388-1981(23)00093-8
doi: 10.1016/j.bbalip.2023.159369
pii:
doi:

Substances chimiques

AMP-Activated Protein Kinases EC 2.7.11.31
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha 0
Coenzyme A SAA04E81UX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

159369

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing interests.

Auteurs

Kaixiang Zhu (K)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Ling Ni (L)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Jianxiong Han (J)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Zhongkang Yan (Z)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Yin Zhang (Y)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Feifei Wang (F)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China.

Lili Wang (L)

School of Life Science, Anhui University, Hefei, Anhui 230601, PR China. Electronic address: wang_lili@ahu.edu.cn.

Xingyuan Yang (X)

Institute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, PR China. Electronic address: xingyuan@ahu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Coactivateurs de récepteurs nucléaires › Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Acetyl-coenzyme A acetyltransferase 1 promotes...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acetyl-coenzyme A acetyltransferase 1 promotes...