The Expression Pattern and Clinical Significance of Lysyl Oxidase Family in Gliomas.

Lysyl oxidase expression pattern functional enrichment gliomas protein-protein interaction network

Journal

Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 20 01 2023
accepted: 09 03 2023
revised: 03 03 2023
medline: 17 8 2023
pubmed: 16 8 2023
entrez: 15 8 2023
Statut: ppublish

Résumé

LOX (Lysyl oxidase) family participates in the catalysis of collagen and elastin to maintain ECM homeostasis. Glioma is the most common primary brain tumor and LOX family has not been systemic studied in glioma. In this study, we found LOX family members are upregulated expressed in gliomas samples. A protein-protein interaction network (PPIN) was construct to visualize and understand the differential expression pattern, as well as functional annotation, for LOX family and their interacting proteins, which involved in collagen fibril organization and MAPK signaling pathway. Through subcellular localization distribution, the LOX family members distribute both intracellular and extracellular. All five LOX members are consistently significantly correlate with dendritic cell both in immune infiltrate of GBM and LGG. Survival analysis showed that high expression of LOX family is associated with a poor prognosis of gliomas patients. These analyses provide important clues to identify the potential biological roles for LOX family in gliomas, which might serve as diagnosis markers.

Identifiants

pubmed: 37582875
doi: 10.1134/S1607672922600269
pii: 10.1134/S1607672922600269
doi:

Substances chimiques

Protein-Lysine 6-Oxidase EC 1.4.3.13
Collagen 9007-34-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

132-143

Informations de copyright

© 2023. Pleiades Publishing, Ltd.

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Auteurs

Weijie Xie (W)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Zhongte Peng (Z)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Xiao Zhou (X)

Department of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.

Qiaoxi Xia (Q)

Department of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.

Mantong Chen (M)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Xiaoqi Zheng (X)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Hong Sun (H)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Haiying Zou (H)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.

Liyan Xu (L)

Institute of Oncologic Pathology, Shantou University Medical College, 515041, Shantou, China.

Zepeng Du (Z)

Department of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.

Enmin Li (E)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China. nmli@stu.edu.cn.

Bingli Wu (B)

Department of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China. blwu@stu.edu.cn.

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