Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 08 2023
24 08 2023
Historique:
medline:
25
8
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due to their significant involvement in cognitive decline associated with neurological disorders and neurodegenerative diseases as well as cardiovascular impairment. Positron emission tomography (PET) is a noninvasive molecular imaging tool that has helped to shed light on the roles these receptors play in disease development and their diverse functions throughout the central nervous system (CNS). In recent years, there has been a notable advancement in the development of PET probes targeting cholinergic receptors. The purpose of this review is to provide a comprehensive overview of the recent progress in the development of these PET probes for cholinergic receptors with a specific focus on ligand structure, radiochemistry, and pharmacology as well as in vivo performance and applications in neuroimaging. The review covers the structural design, pharmacological properties, radiosynthesis approaches, and preclinical and clinical evaluations of current state-of-the-art PET probes for cholinergic receptors.
Identifiants
pubmed: 37583063
doi: 10.1021/acs.jmedchem.3c00573
pmc: PMC10461233
doi:
Substances chimiques
Receptors, Cholinergic
0
Radiopharmaceuticals
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10889-10916Références
Neuroimage. 2008 Jan 15;39(2):717-27
pubmed: 17962044
Pharmacol Rev. 1998 Jun;50(2):279-90
pubmed: 9647869
Brain Res. 2001 Oct 19;916(1-2):22-31
pubmed: 11597587
Brain. 2013 Oct;136(Pt 10):3004-17
pubmed: 23975517
Curr Top Behav Neurosci. 2020;45:1-28
pubmed: 32451956
Biochem Pharmacol. 1993 Jun 9;45(11):2352-4
pubmed: 8100134
Angew Chem Int Ed Engl. 2008;47(47):8998-9033
pubmed: 18988199
Surg Oncol. 2019 Dec;31:46-53
pubmed: 31536927
Synapse. 2007 Sep;61(9):764-70
pubmed: 17568410
J Neurochem. 1999 Oct;73(4):1590-7
pubmed: 10501205
Int J Rad Appl Instrum B. 1992 Nov;19(8):871-80
pubmed: 1428915
Neuropsychopharmacology. 2007 Jan;32(1):17-34
pubmed: 16936709
J Med Chem. 1995 May 12;38(10):1711-9
pubmed: 7752195
Nucl Med Biol. 2015 Jun;42(6):570-7
pubmed: 25858513
J Nucl Med. 2004 May;45(5):878-84
pubmed: 15136639
Science. 1969 Nov 14;166(3907):899-901
pubmed: 5345207
Curr Cardiol Rep. 2015 Aug;17(8):67
pubmed: 26183620
Neuroimage. 2015 Sep;118:199-208
pubmed: 26037057
EJNMMI Res. 2014 Dec;4(1):66
pubmed: 26116126
Appl Radiat Isot. 1999 Mar;50(3):521-5
pubmed: 10070712
Psychopharmacology (Berl). 1998 Apr;136(4):320-7
pubmed: 9600576
Curr Clin Pharmacol. 2019;14(2):91-100
pubmed: 30501602
Pharmaceuticals (Basel). 2021 Jun 02;14(6):
pubmed: 34199622
Synapse. 1990;5(3):213-23
pubmed: 2343375
Prog Neurobiol. 2004 Dec;74(6):363-96
pubmed: 15649582
Dementia. 1996 Jul-Aug;7(4):187-95
pubmed: 8835881
Nucl Med Biol. 2013 Apr;40(3):395-402
pubmed: 23294899
Nucl Med Biol. 2013 Jan;40(1):117-25
pubmed: 23141552
Curr Opin Pharmacol. 2014 Jun;16:24-30
pubmed: 24662799
Eur J Pharmacol. 2009 Mar 1;605(1-3):114-6
pubmed: 19168054
EJNMMI Res. 2020 Jun 12;10(1):61
pubmed: 32533449
J Biol Chem. 2017 Feb 17;292(7):2729-2740
pubmed: 28031459
Life Sci. 1990;47(10):841-8
pubmed: 2215068
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802
pubmed: 9873625
Neurology. 2016 Jul 12;87(2):178-85
pubmed: 27306636
Appl Radiat Isot. 2011 Oct;69(10):1390-4
pubmed: 21605979
Appl Radiat Isot. 2004 Dec;61(6):1235-40
pubmed: 15388115
Proc Natl Acad Sci U S A. 1974 May;71(5):1725-9
pubmed: 4151898
J Nucl Med. 2005 Jan;46(1):130-40
pubmed: 15632043
Neuroscience. 2021 Feb 21;456:60-70
pubmed: 32278062
Adv Pharmacol. 2020;88:277-310
pubmed: 32416870
Nucl Med Biol. 2007 Jul;34(5):541-51
pubmed: 17591554
Nucl Med Biol. 2000 Nov;27(8):733-40
pubmed: 11150704
Nat Commun. 2019 Jun 21;10(1):2746
pubmed: 31227712
Eur J Nucl Med Mol Imaging. 2009 May;36(5):791-800
pubmed: 19137292
Nicotine Tob Res. 2020 May 26;22(6):892-899
pubmed: 31096265
Am J Psychiatry. 2003 Jan;160(1):118-27
pubmed: 12505810
Front Bioeng Biotechnol. 2021 Mar 12;9:640037
pubmed: 33777911
Int J Rad Appl Instrum B. 1991;18(2):247-52
pubmed: 2026502
J Nucl Med. 2008 Oct;49(10):1628-35
pubmed: 18794265
Nucl Med Biol. 2006 Apr;33(3):295-304
pubmed: 16631077
J Med Chem. 2013 Oct 10;56(19):7574-89
pubmed: 24050653
Nat Rev Drug Discov. 2008 Jul;7(7):591-607
pubmed: 18591980
EJNMMI Res. 2013 Mar 21;3(1):19
pubmed: 23514539
J Med Chem. 2020 Mar 12;63(5):2411-2425
pubmed: 32101422
Bioorg Med Chem. 2013 May 1;21(9):2635-42
pubmed: 23507153
Arch Neurol. 1991 Feb;48(2):169-76
pubmed: 1993008
J Nucl Med. 2014 Apr;55(4):672-7
pubmed: 24556591
J Med Chem. 1995 Jan 6;38(1):5-8
pubmed: 7837240
Psychiatry Res Neuroimaging. 2021 Oct 30;316:111354
pubmed: 34399286
ACS Chem Neurosci. 2018 Feb 21;9(2):224-229
pubmed: 29072902
Curr Top Behav Neurosci. 2020;45:209-245
pubmed: 32451955
Neuronal Signal. 2022 Apr 21;6(1):NS20210004
pubmed: 35571495
J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):159-66
pubmed: 24285321
Psychopharmacology (Berl). 1994 Jun;115(1-2):31-6
pubmed: 7862909
Eur J Nucl Med Mol Imaging. 2011 Aug;38(8):1541-9
pubmed: 21484373
J Neural Transm Park Dis Dement Sect. 1990;2(3):215-24
pubmed: 2257061
Molecules. 2020 Jun 23;25(12):
pubmed: 32585815
Neuroreport. 1999 Sep 9;10(13):2715-21
pubmed: 10511429
J Med Chem. 2008 Feb 28;51(4):701-12
pubmed: 18198823
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13541-6
pubmed: 8942969
Biochem Pharmacol. 2007 Oct 15;74(8):1102-11
pubmed: 17597586
EJNMMI Res. 2014 Aug 05;4:43
pubmed: 25136512
Neurobiol Dis. 2020 Jun;139:104831
pubmed: 32145376
Molecules. 2020 Mar 20;25(6):
pubmed: 32245032
J Labelled Comp Radiopharm. 2015 Apr;58(4):180-2
pubmed: 25720955
J Med Chem. 2004 May 6;47(10):2453-65
pubmed: 15115389
Neurosci Lett. 1993 Jan 12;149(2):225-8
pubmed: 8474698
Neuroimage. 2016 Nov 1;141:71-80
pubmed: 27426839
Neuroimage. 2018 Jan 15;165:118-124
pubmed: 28993233
Eur J Med Chem. 2014 Jul 23;82:214-24
pubmed: 24904968
J Nucl Med. 2019 Aug;60(8):1147-1153
pubmed: 30733324
Chem Rev. 2008 May;108(5):1501-16
pubmed: 18426240
Synapse. 2017 Aug;71(8):
pubmed: 28420041
J Mol Biol. 2005 Mar 4;346(4):967-89
pubmed: 15701510
J Nucl Med. 2012 Jan;53(1):121-9
pubmed: 22173841
Acta Pharm Sin B. 2023 Jan;13(1):213-226
pubmed: 36815036
J Nucl Med. 2013 Aug;54(8):1308-14
pubmed: 23801676
Eur J Nucl Med. 1993 May;20(5):379-86
pubmed: 8519256
Int J Neuropsychopharmacol. 2007 Apr;10(2):275-80
pubmed: 16945161
Int J Rad Appl Instrum B. 1989;16(1):51-5
pubmed: 2785511
Am J Geriatr Psychiatry. 2017 Apr;25(4):342-353
pubmed: 28162919
PLoS One. 2008 Sep 18;3(9):e3231
pubmed: 18800169
Curr Pharm Des. 2006;12(30):3901-13
pubmed: 17073686
Arch Neurol. 1991 Nov;48(11):1117-8
pubmed: 1953390
Mol Neurobiol. 1997 Oct;15(2):193-222
pubmed: 9396010
Pharmacol Rev. 2015 Oct;67(4):1025-73
pubmed: 26419447
J Med Chem. 2000 Nov 2;43(22):4045-50
pubmed: 11063601
Bioorg Med Chem. 2014 Jan 15;22(2):804-12
pubmed: 24369841
Synapse. 2001 Sep 1;41(3):248-57
pubmed: 11418938
Int J Rad Appl Instrum A. 1988;39(5):373-9
pubmed: 2840412
Mol Imaging Biol. 2017 Apr;19(2):280-288
pubmed: 27562686
J Med Chem. 2012 Feb 23;55(4):1445-64
pubmed: 22148748
Psychopharmacology (Berl). 2010 Sep;212(1):1-12
pubmed: 20614106
Nucl Med Biol. 2013 Aug;40(6):731-9
pubmed: 23680470
CNS Neurosci Ther. 2008 Spring;14(1):65-82
pubmed: 18482100
Bioorg Med Chem. 1997 Aug;5(8):1555-67
pubmed: 9313861
Appl Radiat Isot. 2015 Jan;95:76-84
pubmed: 25464181
FEBS Lett. 2001 Aug 31;504(3):118-25
pubmed: 11532443
Synapse. 2001 Jun 1;40(3):159-69
pubmed: 11304753
PLoS One. 2012;7(12):e51515
pubmed: 23240035
Eur J Nucl Med Mol Imaging. 2006 Mar;33(3):292-300
pubmed: 16333673
Eur J Pharmacol. 1992 Jul 7;217(2-3):173-84
pubmed: 1425938
FASEB J. 2003 Jul;17(10):1331-3
pubmed: 12759330
Sci Transl Med. 2022 Jan 12;14(627):eabg3684
pubmed: 35020407
Int J Rad Appl Instrum A. 1988;39(4):291-5
pubmed: 2838435
Life Sci. 1991;48(14):1385-94
pubmed: 2008155
Ann Nucl Med. 2009 May;23(3):301-9
pubmed: 19337782
Nat Rev Drug Discov. 2014 Jul;13(7):549-60
pubmed: 24903776
Biochem Pharmacol. 2015 Oct 15;97(4):566-575
pubmed: 26232729
J Cereb Blood Flow Metab. 1994 Jan;14(1):85-99
pubmed: 8263062
Trends Pharmacol Sci. 2006 Sep;27(9):482-91
pubmed: 16876883
J Nucl Med. 2005 Feb;46(2):326-34
pubmed: 15695794
Nature. 2016 Mar 17;531(7594):335-40
pubmed: 26958838
J Cereb Blood Flow Metab. 1996 Nov;16(6):1280-7
pubmed: 8898702
ChemMedChem. 2019 Feb 5;14(3):303-309
pubmed: 30589226
J Pharmacol Exp Ther. 2018 Jun;365(3):602-613
pubmed: 29643252
J Nucl Med. 2011 Sep;52(9):1449-56
pubmed: 21828113
ChemMedChem. 2019 May 6;14(9):943-951
pubmed: 30920765
Eur J Pharmacol. 1992 Mar 24;213(2):275-84
pubmed: 1521561
Nature. 1998 Jan 8;391(6663):173-7
pubmed: 9428762
Life Sci. 2010 Apr 10;86(15-16):575-84
pubmed: 19303028
J Cereb Blood Flow Metab. 1992 Jan;12(1):147-54
pubmed: 1727135
J Nucl Med. 1985 Jun;26(6):637-42
pubmed: 3998853
ACS Med Chem Lett. 2016 Dec 16;8(2):233-238
pubmed: 28197318
Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):537-47
pubmed: 26455500
PLoS One. 2010 Feb 01;5(2):e8961
pubmed: 20126539
Bioorg Med Chem. 2006 Jun 1;14(11):3848-58
pubmed: 16455259
Synapse. 2003 Apr;48(1):39-44
pubmed: 12557271
Curr Top Behav Neurosci. 2020;45:89-99
pubmed: 32451954
Brain Res Mol Brain Res. 2000 Mar 29;76(2):385-8
pubmed: 10762715
Appl Radiat Isot. 1997 Apr;48(4):463-7
pubmed: 9106987
J Neurol. 2015 Sep;262(9):2144-53
pubmed: 26122542
J Nucl Med. 2018 Oct;59(10):1603-1608
pubmed: 29496987
Eur J Med Chem. 2018 Nov 5;159:255-266
pubmed: 30296684
J Nucl Med. 1984 Feb;25(2):214-22
pubmed: 6726431
Science. 1984 Jan 20;223(4633):291-3
pubmed: 6608148
Arch Gen Psychiatry. 2009 Aug;66(8):866-77
pubmed: 19652126
J Nucl Med. 2022 Jun;63(Suppl 1):33S-44S
pubmed: 35649648
Arch Gen Psychiatry. 2006 Jun;63(6):630-8
pubmed: 16754836
Appl Radiat Isot. 2016 Aug;114:57-62
pubmed: 27183376
Brain Neurosci Adv. 2019 Mar 21;3:2398212818820506
pubmed: 32166177
Curr Top Behav Neurosci. 2020;45:71-87
pubmed: 32447715
J Chem Neuroanat. 2003 Mar;25(3):161-73
pubmed: 12706204
Acta Neurol Scand. 2014 Sep;130(3):164-71
pubmed: 24762290
Neuropsychopharmacology. 2007 Jan;32(1):1-16
pubmed: 17019409
J Nucl Med. 2021 Apr;62(4):553-560
pubmed: 32859711
Synapse. 2012 Apr;66(4):315-22
pubmed: 22108786
J Med Chem. 2008 Aug 14;51(15):4751-64
pubmed: 18605717
Biochem Pharmacol. 2011 Oct 15;82(8):891-903
pubmed: 21741954
Am J Psychiatry. 2008 Aug;165(8):1040-7
pubmed: 18381905
Curr Top Behav Neurosci. 2020;45:101-121
pubmed: 32468493
Trends Pharmacol Sci. 2019 Dec;40(12):1006-1020
pubmed: 31711626
Brain Res. 1994 May 9;645(1-2):309-17
pubmed: 8062092
Neuropharmacology. 2003 Apr;44(5):653-61
pubmed: 12668051
J Neurosci. 1988 Dec;8(12):4646-52
pubmed: 3199198
Neuropsychopharmacology. 2011 Jun;36(7):1455-65
pubmed: 21430646
Br J Pharmacol. 2008 Aug;154(8):1558-71
pubmed: 18500366
Neuropsychopharmacology. 2015 Dec;40(13):3053-60
pubmed: 26089183
Front Neurosci. 2020 Nov 25;14:609005
pubmed: 33324158
J Cereb Blood Flow Metab. 1996 Mar;16(2):303-10
pubmed: 8594063
Biol Pharm Bull. 2009 Mar;32(3):337-40
pubmed: 19252274
J Neurol. 2007 Jul;254(7):907-13
pubmed: 17361343
Neuropsychopharmacology. 2013 May;38(6):968-75
pubmed: 23303043
J Pharm Sci. 1989 Oct;78(10):833-6
pubmed: 2600789
Neuroimage. 2011 Sep 1;58(1):1-9
pubmed: 21712096
Mol Psychiatry. 2019 May;24(5):694-709
pubmed: 30120418
Nucl Med Biol. 1996 Apr;23(3):235-43
pubmed: 8782231
Nucl Med Biol. 2011 Nov;38(8):1183-92
pubmed: 21831652
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1042-1050
pubmed: 28120003
Neuropharmacology. 2020 Oct 15;177:108256
pubmed: 32738308
Curr Top Med Chem. 2016;16(16):1830-42
pubmed: 26975506
Cereb Cortex. 2021 May 10;31(6):2787-2798
pubmed: 33442731
J Med Chem. 1992 Jun 12;35(12):2274-83
pubmed: 1613751
Mol Imaging Biol. 2014 Oct;16(5):730-8
pubmed: 25145965
J Mol Neurosci. 2005;27(1):13-21
pubmed: 16055943