Malignant mesothelioma cells with characteristic intracytoplasmic vacuolization and lipids.
cytology
foamy cells
lipids
malignant mesothelioma
pleural effusion
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
28
07
2023
received:
17
04
2023
accepted:
31
07
2023
medline:
2
11
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
In this brief report, we described some uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. The tumor cells exhibited abundant cytoplasmic vacuolization, with presence of single or multiple eccentric nuclei in several cells. In the Giemsa-stained smear, we observed a glossy spherical material in some cells, which tested positive in Sudan III stain. In immunocytochemical analysis, tumor cells were positive for calretinin, podoplanin, epithelial membrane antigen, and methylthioadenosine phosphorylase; tumor cells were negative for BRCA1-associated protein 1, CD68, and desmin. The intracytoplasmic vacuoles were positive for adipophilin expression.
Substances chimiques
Coloring Agents
0
Lipids
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E328-E331Subventions
Organisme : JSPS KAKENHI
ID : 22K07396
Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
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