Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV.

Humans HIV Interleukin-10 Interleukin-6 Dysbiosis HIV Infections / drug therapy Cytokines
HIV infection bacterial strain diversity chronic inflammation cytokine producing capacity human gut microbiome

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2023
Historique:
received: 07 04 2023
accepted: 06 07 2023
medline: 17 8 2023
pubmed: 16 8 2023
entrez: 16 8 2023
Statut: epublish

Résumé

People living with human immunodeficiency virus (PLHIV) are exposed to chronic immune dysregulation, even when virus replication is suppressed by antiretroviral therapy (ART). Given the emerging role of the gut microbiome in immunity, we hypothesized that the gut microbiome may be related to the cytokine production capacity of PLHIV. To test this hypothesis, we collected metagenomic data from 143 ART-treated PLHIV and assessed the Compared with 190 age- and sex-matched controls and a second independent control cohort, PLHIV showed microbial dysbiosis that was correlated with viral reservoir levels (CD4 Our findings suggest that modulating the gut microbiome may be a strategy to modulate immune response in PLHIV.

Sections du résumé

Background
People living with human immunodeficiency virus (PLHIV) are exposed to chronic immune dysregulation, even when virus replication is suppressed by antiretroviral therapy (ART). Given the emerging role of the gut microbiome in immunity, we hypothesized that the gut microbiome may be related to the cytokine production capacity of PLHIV.
Methods
To test this hypothesis, we collected metagenomic data from 143 ART-treated PLHIV and assessed the
Results
Compared with 190 age- and sex-matched controls and a second independent control cohort, PLHIV showed microbial dysbiosis that was correlated with viral reservoir levels (CD4
Conclusions
Our findings suggest that modulating the gut microbiome may be a strategy to modulate immune response in PLHIV.

Identifiants

DOI: 10.3389/fcimb.2023.1202035 PMID: 37583444 PMC: PMC10425223
pubmed: 37583444
doi: 10.3389/fcimb.2023.1202035
pmc: PMC10425223
doi:

Substances chimiques

Interleukin-10 130068-27-8
Interleukin-6 0
Cytokines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1202035

Informations de copyright

Copyright © 2023 Zhang, Andreu-Sánchez, Vadaq, Wang, Matzaraki, van der Heijden, Gacesa, Weersma, Zhernakova, Vandekerckhove, de Mast, Joosten, Netea, van der Ven and Fu.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Yue Zhang (Y)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Sergio Andreu-Sánchez (S)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Nadira Vadaq (N)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Daoming Wang (D)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Vasiliki Matzaraki (V)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Wouter A van der Heijden (WA)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Ranko Gacesa (R)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands.

Rinse K Weersma (RK)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands.

Alexandra Zhernakova (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Linos Vandekerckhove (L)

HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium.

Quirijn de Mast (Q)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Leo A B Joosten (LAB)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Mihai G Netea (MG)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

André J A M van der Ven (AJAM)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Jingyuan Fu (J)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Gut dysbiosis associates with cytokine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Gut dysbiosis associates with cytokine...