A case of low-grade intestinal-type mucinous neoplasm of the fallopian tube with KRAS exon 2 mutation.
Fallopian tube
Intestinal-type mucinous neoplasm
KRAS mutation
Journal
Gynecologic oncology reports
ISSN: 2352-5789
Titre abrégé: Gynecol Oncol Rep
Pays: Netherlands
ID NLM: 101652231
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
15
06
2023
revised:
27
07
2023
accepted:
29
07
2023
medline:
16
8
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
epublish
Résumé
Several types of mucinous lesions of the fallopian tube have been reported, including metaplastic and neoplastic lesions, most of which exhibit gastric phenotypes. Here, we report a unique case of a mucinous tumor arising in the right fallopian tube of a 36-year-old female who presented with refractory abdominal pain for approximately one year. Abdominal CT and MRI found a cystic lesion leading to the diagnosis of hematosalpinx, thus right salpingo-oophorectomy and appendectomy were performed. Macroscopic findings included cystic dilatation of the distal portion of the right fallopian tube, filled with gelatinous mucin. Histologically, mucinous columnar cells proliferated in papillary configurations in the cystic region without invasion, resembling low-grade appendiceal mucinous neoplasms. Immunohistochemical analysis revealed that the neoplastic cells expressed CDX-2 and SATB2, but not WT-1, PAX8, ER, PgR, or claudin 18. Sanger sequencing of the mucinous lesion identified a KRAS exon 2 mutation (p.G12A), confirming similar pathologic and genetic characteristics to ovarian mucinous borderline tumors. This rare low grade intestinal-type mucinous tumor indicates the fallopian tube epithelium can give rise to tumors resembling low-grade appendiceal mucinous neoplasms and cause pseudomyxoma peritonei without appendiceal lesions.
Identifiants
pubmed: 37583589
doi: 10.1016/j.gore.2023.101252
pii: S2352-5789(23)00121-2
pmc: PMC10424131
doi:
Types de publication
Case Reports
Langues
eng
Pagination
101252Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Gastroenterology. 1986 Jan;90(1):202-5
pubmed: 2998918
Case Rep Pathol. 2013;2013:608016
pubmed: 24024058
N Engl J Med. 2022 Jul 14;387(2):120-131
pubmed: 35658005
Am J Clin Pathol. 1980 Aug;74(2):232-6
pubmed: 7405904
BMC Cancer. 2020 May 8;20(1):400
pubmed: 32384877
J Gastroenterol. 1994 Jun;29(3):344-8
pubmed: 8061804
Cancer Res. 1994 Jan 1;54(1):33-5
pubmed: 8261457
Int J Gynecol Pathol. 2001 Jul;20(3):244-51
pubmed: 11444200
J Surg Oncol. 2000 Dec;75(4):270-4
pubmed: 11135270
N Engl J Med. 2019 Mar 28;380(13):1256-1266
pubmed: 30917260
Am J Pathol. 1991 Oct;139(4):777-85
pubmed: 1656759
Gynecol Oncol. 2017 Jul;146(1):3-10
pubmed: 28372871
Am J Surg Pathol. 1994 Dec;18(12):1205-12
pubmed: 7977943
Int J Gynecol Pathol. 2011 Jan;30(1):36-40
pubmed: 21131836
Histopathology. 2009 Jan;54(2):184-91
pubmed: 19207943
Mod Pathol. 2013 Jun;26(6):825-34
pubmed: 23348904
Int J Gynecol Pathol. 2017 Jul;36(4):393-399
pubmed: 27662036