Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity.

Humans Insulin Resistance / physiology Diabetes Mellitus, Type 2 / metabolism Mitochondria Muscle, Skeletal / metabolism Obesity / metabolism Mitochondria, Muscle / metabolism
insulin resistance mitochondrial capacity skeletal muscle type 2 diabetes

Journal

American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226

Informations de publication

Date de publication:
01 10 2023
Historique:
medline: 22 9 2023
pubmed: 16 8 2023
entrez: 16 8 2023
Statut: ppublish

Résumé

Insulin resistance and blunted mitochondrial capacity in skeletal muscle are often synonymous, however, this association remains controversial. The aim of this study was to perform an in-depth multifactorial comparison of skeletal muscle mitochondrial capacity between individuals who were lean and active (Active,

Identifiants

DOI: 10.1152/ajpendo.00143.2023 PMID: 37584609
pubmed: 37584609
doi: 10.1152/ajpendo.00143.2023
doi:

Banques de données

ClinicalTrials.gov
['NCT01911104']
figshare
['10.6084/m9.figshare.22779239']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

E291-E302

Auteurs

Katie L Whytock (KL)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.
ORCID: 0000-0003-3486-9452

Maria F Pino (MF)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Yifei Sun (Y)

Icahn School of Medicine at Mount Sinai, New York City, New York, United States.

GongXin Yu (G)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Flavia G De Carvalho (FG)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Reichelle X Yeo (RX)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.
ORCID: 0000-0002-2403-6150

Rick B Vega (RB)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Gaganvir Parmar (G)

Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.

Adeline Divoux (A)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Nidhi Kapoor (N)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Fancaho Yi (F)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Heather Cornnell (H)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

David A Patten (DA)

Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.

Mary-Ellen Harper (ME)

Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.
ORCID: 0000-0003-3864-5886

Stephen J Gardell (SJ)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Steven R Smith (SR)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Martin J Walsh (MJ)

Icahn School of Medicine at Mount Sinai, New York City, New York, United States.

Lauren M Sparks (LM)

Translational Research Institute, AdventHealth, Orlando, Florida, United States.
ORCID: 0000-0002-8724-6016

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Comprehensive interrogation of human skeletal...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Comprehensive interrogation of human skeletal...