Microplastics: unraveling the signaling pathways involved in reproductive health.
Birth defects
Microplastics
Oogenesis
Oxidative stress
Spermatogenesis
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
27
12
2022
accepted:
07
08
2023
medline:
8
9
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Microplastics (MPs) are biologically active environmental pollutants having significant impact on the ecosystem and human health. MPs have been reported to increase oxidative stress, resulting in tissue damage, developmental abnormalities, metabolic disorders, epigenetic changes, abnormal reproduction, and reduced gamete quality. At present, most of the existing literature has focused on the effects of MPs on the reproduction of various aquatic organisms; however, the effects of MPs on mammalian reproduction specifically humans are least studied except a few ones fragmentally discussing the effects of MPs on gametogenesis in human. This review discusses effects of MPs on male and female reproduction with a focus on different metabolic pathways involved in compromised gamete quality, gamete toxicity, apoptosis, and DNA damage.
Identifiants
pubmed: 37584803
doi: 10.1007/s11356-023-29273-3
pii: 10.1007/s11356-023-29273-3
doi:
Substances chimiques
Microplastics
0
Plastics
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
95077-95085Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
An R, Wang X, Yang L, Zhang J, Wang N, Xu F, Hou Y, Zhang H, Zhang L (2021) Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats. Toxicology 449:152665
Asharani P, Low Kah Mun G, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3(2):279–290
Benoff S, Hauser R, Marmar JL, Hurley IR, Napolitano B, Centola GM (2009) Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers). Mol Med 15(7):248–262
Braun T, Ehrlich L, Henrich W, Koeppel S, Lomako I, Schwabl P, Liebmann B (2021) Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics 13(7):921
Charan HV, Dwivedi DK, Khan S, Jena G (2023) Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis. Genes Dis 10(2):480–494. https://doi.org/10.1016/j.gendis.2021.12.006
doi: 10.1016/j.gendis.2021.12.006
Cheng CY, Wong EW, Lie PP, Li MW, Su L, Siu ER, Yan HH, Mannu J, Mathur PP, Bonanomi M (2011) Environmental toxicants and male reproductive function. Spermatogenesis 1(1):2–13
Chihara M, Otsuka S, Ichii O, Kon Y (2013) Vitamin A deprivation affects the progression of the spermatogenic wave and initial formation of the blood-testis barrier, resulting in irreversible testicular degeneration in mice. J Reprod Dev 59(6):525–535
Choy CM, Yeung QS, Briton-Jones CM, Cheung C-K, Lam CW, Haines CJ (2002) Relationship between semen parameters and mercury concentrations in blood and in seminal fluid from subfertile males in Hong Kong. Fertil Steril 78(2):426–428
D’Angelo S, Meccariello R (2021) Microplastics: a threat for male fertility. Int J Environ Res Public Health 18(5):2392
Darbandi M, Darbandi S, Agarwal A, Sengupta P, Durairajanayagam D, Henkel R, Sadeghi MR (2018) Reactive oxygen species and male reproductive hormones. Reprod Biol Endocrinol 16(1):1–14
de Rivero Vaccari JP (2020) The inflammasome in reproductive biology: a promising target for novel therapies. Front Endocrinol 11:8
Diaz-Basantes M, Conesa J, Fullana A (2020) Microplastics in honey, beer, milk and refreshments in Ecuador as emerging contaminants. Sustainability 12:5514
Eder ML, Oliva-Teles L, Pinto R, Carvalho AP, Almeida CMR, Hornek-Gausterer R, Guimaraes L (2021) Microplastics as a vehicle of exposure to chemical contamination in freshwater systems: current research status and way forward. J Hazard Mater 417:125980
Felten V, Toumi H, Masfaraud J-F, Billoir E, Camara BI, Férard J-F (2020) Microplastics enhance Daphnia magna sensitivity to the pyrethroid insecticide deltamethrin: effects on life history traits. Sci Total Environ 714:136567
Feng Y, Yuan H, Wang W, Xu Y, Zhang J, Xu H, Fu F (2022) Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK/eIF2α signaling pathway. Ecotoxicol Environ Saf 243:113966
Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH (2004) A role for NF-κB subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 173(9):5786–5793
Grippo A, Zhang J, Chu L, Guo Y, Qiao L, Zhang J, Myneni AA, Mu L (2018) Air pollution exposure during pregnancy and spontaneous abortion and stillbirth. Rev Environ Health 33(3):247–264
Güven M, Bayram F, Ünlühizarci K, Kelestimur F (1999) Endocrine changes in patients with acute organophosphate poisoning. Hum Exp Toxicol 18(10):598–601
Haddadi A, Kessabi K, Boughammoura S, Rhouma MB, Mlouka R, Banni M, Messaoudi I (2022) Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat. Environ Sci Pollut Res 29(23):34594–34606
Horton AA, Newbold LK, Palacio-Cortés AM, Spurgeon DJ, Pereira MG, Carter H, Gweon HS, Vijver MG, Van Bodegom PM, da Silva MAN (2020) Accumulation of polybrominated diphenyl ethers and microbiome response in the great pond snail Lymnaea stagnalis with exposure to nylon (polyamide) microplastics. Ecotoxicol Environ Saf 188:109882
Hou B, Wang F, Liu T, Wang Z (2021a) Reproductive toxicity of polystyrene microplastics: in vivo experimental study on testicular toxicity in mice. J Hazard Mater 405:124028
Hou J, Lei Z, Cui L, Hou Y, Yang L, An R, Wang Q, Li S, Zhang H, Zhang L (2021b) Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats. Ecotoxicol Environ Saf 212:112012
Hu J, Qin X, Zhang J, Zhu Y, Zeng W, Lin Y, Liu X (2021) Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice. Reprod Toxicol 106:42–50
Ijaz MU, Shahzadi S, Samad A, Ehsan N, Ahmed H, Tahir A, Rehman H, Anwar H (2021) Dose-dependent effect of polystyrene microplastics on the testicular tissues of the male Sprague Dawley rats. Dose-Response 19(2):15593258211019882
Jewett E, Arnott G, Connolly L, Vasudevan N, Kevei E (2022) Microplastics and their impact on reproduction—can we learn from the C. elegans model? Front Toxicol 4:748912
Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X, Chen Y, Han X, Ding J (2021) Polystyrene microplastics induced male reproductive toxicity in mice. J Hazard Mater 401:123430
Kaminska B (2005) MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta - Proteins Proteom 1754(1–2):253–262
Khodapasand E, Jafarzadeh N, Farrokhi F, Kamalidehghan B, Houshmand M (2015) Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer? Iran Biomed J 19(2):69
Kwak JI, An Y-J (2021) Microplastic digestion generates fragmented nanoplastics in soils and damages earthworm spermatogenesis and coelomocyte viability. J Hazard Mater 402:124034
Lestari P (2020) Plastics and its effect to women reproductive systems. Majalah Obstetri Dan Ginekologi 28(1):1–2
Li S, Wang Q, Yu H, Yang L, Sun Y, Xu N, Wang N, Lei Z, Hou J, Jin Y (2021) Polystyrene microplastics induce blood–testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats. Environ Sci Pollut Res 28(35):47921–47931
Liu B, Shen L-J, Zhao T-X, Sun M, Wang J-K, Long C-L, He D-W, Lin T, Wei G-H (2020) Automobile exhaust-derived PM25 induces blood-testis barrier damage through ROS-MAPK-Nrf2 pathway in sertoli cells of rats. Ecotoxicol Environ Saf 189:110053
Liu C, Li J, Zhang Y, Wang L, Deng J, Gao Y, Yu L, Zhang J, Sun H (2019) Widespread distribution of PET and PC microplastics in dust in urban China and their estimated human exposure. Environ Int 128:116–124
Liu J, Ren L, Wei J, Zhang J, Zhu Y, Li X, Jing L, Duan J, Zhou X, Sun Z (2018) Fine particle matter disrupts the blood–testis barrier by activating TGF-β3/p38 MAPK pathway and decreasing testosterone secretion in rat. Environ Toxicol 33(7):711–719
Liu S, Shi J, Wang J, Dai Y, Li H, Li J, Liu X, Chen X, Wang Z, Zhang P (2021) Interactions between microplastics and heavy metals in aquatic environments: a review. Front Microbiol 12:730
Liu Z, Zhuan Q, Zhang L, Meng L, Fu X, Hou Y (2022) Polystyrene microplastics induced female reproductive toxicity in mice. J Hazard Mater 424:127629
Meeker JD, Rossano MG, Protas B, Padmanahban V, Diamond MP, Puscheck E, Daly D, Paneth N, Wirth JJ (2010) Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum. Fertil Steril 93(1):130–140
Mruk DD, Cheng C (2010) Tight junctions in the testis: new perspectives. Philos Trans R Soc B: Biol Sci 365(1546):1621–1635
Oßmann BE, Sarau G, Holtmannspötter H, Pischetsrieder M, Christiansen SH, Dicke W (2018) Small-sized microplastics and pigmented particles in bottled mineral water. Water Res 141:307–316
Pironti C, Ricciardi M, Motta O, Miele Y, Proto A, Montano L (2021) Microplastics in the environment: intake through the food web, human exposure and toxicological effects. Toxics 9(9):224
Prata JC, da Costa JP, Lopes I, Duarte AC, Rocha-Santos T (2020) Environmental exposure to microplastics: an overview on possible human health effects. Sci Total Environ 702:134455
Prokić MD, Gavrilović BR, Radovanović TB, Gavrić JP, Petrović TG, Despotović SG, Faggio C (2021) Studying microplastics: lessons from evaluated literature on animal model organisms and experimental approaches. J Hazard Mater 414:125476
Qiang L, Cheng J (2021) Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio). Chemosphere 263:128161
Ragusa A, Matta M, Cristiano L, Matassa R, Battaglione E, Svelato A, De Luca C, D’Avino S, Gulotta A, Rongioletti MCA (2022) Deeply in plasticenta: presence of microplastics in the intracellular compartment of human placentas. Int J Environ Res Public Health 19(18):11593
Ragusa A, Svelato A, Santacroce C, Catalano P, Notarstefano V, Carnevali O, Papa F, Rongioletti MCA, Baiocco F, Draghi S (2021a) Plasticenta: first evidence of microplastics in human placenta. Environ Int 146:106274
Ragusa A, Svelato A, Santacroce C, Catalano P, Notarstefano V, Carnevali O, Papa F, Rongioletti MCA, Baiocco F, Draghi S, D’Amore E, Rinaldo D, Matta M, Giorgini E (2021b) Plasticenta: First evidence of microplastics in human placenta. Environ Int 146:106274. https://doi.org/10.1016/j.envint.2020.106274
Rai PK, Lee J, Brown RJ, Kim K-H (2021) Environmental fate, ecotoxicity biomarkers, and potential health effects of micro-and nano-scale plastic contamination. J Hazard Mater 403:123910
Raish M, Ahmad A, Ansari MA, Alkharfy KM, Aljenoobi FI, Jan BL, Al-Mohizea AM, Khan A, Ali N (2018) Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition. Int J Biol Macromol 111:193–199
Sano M, Komiyama H, Shinoda R, Ozawa R, Watanabe H, Karasawa T, Takahashi M, Torii Y, Iwata H, Kuwayama T (2022) NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice. Am J Reprod Immunol 87(4):e13527
Sarasamma S, Audira G, Siregar P, Malhotra N, Lai Y-H, Liang S-T, Chen J-R, Chen KH-C, Hsiao C-D (2020) Nanoplastics cause neurobehavioral impairments, reproductive and oxidative damages, and biomarker responses in zebrafish: throwing up alarms of wide spread health risk of exposure. Int J Mol Sci 21(4):1410
Sharma RP, Schuhmacher M, Kumar V (2017) Review on crosstalk and common mechanisms of endocrine disruptors: scaffolding to improve PBPK/PD model of EDC mixture. Environ Int 99:1–14
Shimon I, Lubina A, Gorfine M, Ilany J (2006) Feedback inhibition of gonadotropins by testosterone in men with hypogonadotropic hypogonadism: comparison to the intact pituitary-testicular axis in primary hypogonadism. J Androl 27(3):358–364
Silvestris E, Lovero D, Palmirotta R (2019) Nutrition and female fertility: an interdependent correlation. Front Endocrinol (Lausanne) 10:346
Trotter B, Wilde MV, Brehm J, Dafni E, Aliu A, Arnold GJ, Fröhlich T, Laforsch C (2021) Long-term exposure of Daphnia magna to polystyrene microplastic (PS-MP) leads to alterations of the proteome, morphology and life-history. Sci Total Environ 795:148822
Wang J, Li Y, Lu L, Zheng M, Zhang X, Tian H, Wang W, Ru S (2019) Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma). Environ Pollut 254:113024
Wei Z, Wang Y, Wang S, Xie J, Han Q, Chen M (2022) Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice. Toxicology 465:153059
Welshons WV, Nagel SC, vom Saal FS (2006) Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 147(6):s56–s69
Wu H, Xu T, Chen T, Liu J, Xu S (2022) Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice. Sci Total Environ 838:155825
Xie X, Deng T, Duan J, Xie J, Yuan J, Chen M (2020) Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway. Ecotoxicol Environ Saf 190:110133
Yao Y-D, Shen X-Y, Machado J, Luo J-F, Dai Y, Lio C-K, Yu Y, Xie Y, Luo P, Liu J-X (2019) Nardochinoid B inhibited the activation of RAW264. 7 macrophages stimulated by lipopolysaccharide through activating the Nrf2/HO-1 pathway. Molecules 24(13):2482
Yucel C, Arslan FD, Ekmekci S, Ulker V, Kisa E, Yucel EE, Ucar M, Ilbey YO, Celik O, Basok BI (2019) Protective effect of all-trans retinoic acid in cisplatin-induced testicular damage in rats. World J Mens Health 37(2):249
Zhang C, Chen J, Ma S, Sun Z, Wang Z (2022) Microplastics may be a significant cause of male infertility. Am J Mens Health 16(3):15579883221096548
Zhang D-M, Guo Z-X, Zhao Y-L, Wang Q-J, Gao Y-S, Yu T, Chen Y-K, Chen X-M, Wang G-Q (2019) L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling pathway in Rhynchocypris lagowski Dybowski. Fish Shellfish Immunol 93:1100–1110