Mepitel film for the prevention and treatment of acute radiation dermatitis in breast cancer: a systematic review and meta-analysis of randomized controlled trials.
Mepitel film
acute radiation dermatitis
breast cancer
patient reported outcomes, meta-analysis
skin toxicity
systematic review
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
16 Aug 2023
16 Aug 2023
Historique:
received:
17
05
2023
accepted:
01
08
2023
medline:
17
8
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
epublish
Résumé
This systematic review and meta-analysis aimed to evaluate the efficacy of Mepitel film in preventing or treating acute radiation dermatitis (RD) in patients with breast cancer in randomized controlled trials (RCTs). Embase, APA PsychInfo, Journals@Ovid Full Text, Ovid MEDLINE, PubMed, and Cochrane Trials were searched until December 12, 2022, to identify RCTs on the use of Mepitel film for preventing or treating acute RD from breast cancer radiotherapy. Per-protocol analysis was used to compare outcomes, calculate pooled effect sizes, odds ratio (OR), and 95% confidence intervals (CI), and to create forest plots using random effects analysis in RevMan 5.4. Three RCTs were included in this review. Mepitel film significantly reduced the incidence of grade 3 RD (OR 0.15 95% CI 0.06, 0.37, p<0.0001) and grade 2 or 3 RD (OR 0.16 95% CI 0.04, 0.65, p=0.01) as scored on either the CTCAE or the RTOG scale. Additionally, Mepitel film significantly reduced RISRAS mean scores assessed by patients and combined researcher and patient (standardized mean difference (SMD) -7.59, 95% CI -14.42, -0.76, p=0.03; SMD -15.36, 95% CI -30.01, -0.71 p=0.04) but not the researcher component of the assessment tool (SMD -17.55, 95% CI -36.94, 1.84, p=0.08). Mepitel film reduced the incidence of acute RD and improved patient-reported outcomes with minimal side effects, the main one being itchiness. Future research should assess the feasibility of Mepitel film with respect to specific patient-reported outcomes such as health-related quality of life issues associated with its use.
Identifiants
pubmed: 37584828
doi: 10.1007/s00520-023-07982-2
pii: 10.1007/s00520-023-07982-2
doi:
Substances chimiques
mepitel
0
Silicones
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
524Informations de copyright
© 2023. Crown.
Références
Kole AJ, Kole L, Moran M (2017) Acute radiation dermatitis in breast cancer patients: challenges and solutions. Breast Cancer Targets Ther 9:313–323
doi: 10.2147/BCTT.S109763
Alexopoulou E, Katsila T, Tolia M, Tsoukalas N, Leontsinidis M, Kyrgias G et al (2018) An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients. Anticancer Res 38(3):1615–1622
pubmed: 29491093
Radiation Dermatitis: Recognition, Prevention, and Management [Internet]. Cancer Network. Available from: https://www.cancernetwork.com/view/radiation-dermatitis-recognition-prevention-and-management
de Andrade Fuzissaki M, Paiva CE, de Oliveira MA, Canto PPL, de Paiva Maia YC (2019) The Impact of Radiodermatitis on Breast Cancer Patients’ Quality of Life during Radiotherapy: A Prospective Cohort Study. J Pain Symptom Manage 58(1):92–99.e1
doi: 10.1016/j.jpainsymman.2019.03.017
Sherman DW, Walsh SM (2022) Promoting Comfort: A Clinician Guide and Evidence-Based Skin Care Plan in the Prevention and Management of Radiation Dermatitis for Patients with Breast Cancer. Healthcare 10(8):1496
doi: 10.3390/healthcare10081496
pubmed: 36011153
pmcid: 9408725
Finkelstein S, Kanee L, Behroozian T, Wolf JR, van den Hurk C, Chow E et al (2022) Comparison of clinical practice guidelines on radiation dermatitis: a narrative review. Support Care Cancer 30(6):4663–4674
doi: 10.1007/s00520-022-06829-6
pubmed: 35067732
Chan RJ, Webster J, Chung B, Marquart L, Ahmed M, Garantziotis S (2014) Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer 14(1):53
doi: 10.1186/1471-2407-14-53
pubmed: 24484999
pmcid: 3909507
Shaw SZ, Nien HH, Wu CJ, Lui LT, Su JF, Lang CH (2015) 3M Cavilon No-Sting Barrier Film or topical corticosteroid (mometasone furoate) for protection against radiation dermatitis: A clinical trial. J Formos Med Assoc 114(5):407–414
doi: 10.1016/j.jfma.2013.04.003
pubmed: 23685085
Schmeel LC, Koch D, Stumpf S, Leitzen C, Simon B, Schüller H et al (2018) Prophylactically applied Hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients. Acta Oncol 57(7):908–915
doi: 10.1080/0284186X.2018.1441542
pubmed: 29463159
Graham P, Browne L, Capp A, Fox C, Graham J, Hollis J et al (2004) Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation. Int J Radiat Oncol Biol Phys 58(1):241–246
doi: 10.1016/S0360-3016(03)01431-7
pubmed: 14697444
Graham PH, Plant N, Graham JL, Browne L, Borg M, Capp A et al (2013) A paired, double-blind, randomized comparison of a moisturizing durable barrier cream to 10% glycerine cream in the prophylactic management of postmastectomy irradiation skin care: trans-Tasman Radiation Oncology Group (TROG) 04.01. Int J Radiat Oncol Biol Phys 86(1):45–50
doi: 10.1016/j.ijrobp.2012.12.009
pubmed: 23414763
Xie Y, Wang Q, Hu T, Chen R, Wang J, Chang H et al (2021) Risk Factors Related to Acute Radiation Dermatitis in Breast Cancer Patients After Radiotherapy: A Systematic Review and Meta-Analysis. Front Oncol 29(11):738851
doi: 10.3389/fonc.2021.738851
Haruna F, Lipsett A, Marignol L (2017) Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Anticancer Res 37(10):5343–5353
pubmed: 28982842
Herst PM (2014) Protecting the radiation-damaged skin from friction: a mini review. J Med Radiat Sci 61(2):119–125
doi: 10.1002/jmrs.46
pubmed: 26229646
pmcid: 4175840
McQuestion M (2011) Evidence-based skin care management in radiation therapy: clinical update. Semin Oncol Nurs 27(2):e1–e17
doi: 10.1016/j.soncn.2011.02.009
pubmed: 21514477
Yee C, Lam E, Gallant F, Karam I, Czarnota G, Soliman H et al (2021) A Feasibility Study of Mepitel Film for the Prevention of Breast Radiation Dermatitis in a Canadian Center. Pract Radiat Oncol 11(1):e36–e45
doi: 10.1016/j.prro.2020.09.004
pubmed: 32949772
Yan J, Yuan L, Wang J, Li S, Yao M, Wang K et al (2020) Mepitel Film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: a randomised intra-patient controlled clinical trial. J Med Radiat Sci 67(3):208–216
doi: 10.1002/jmrs.397
pubmed: 32475079
pmcid: 7476193
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J et al (2022) Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial. J Clin Oncol 41(6):1250–1264
doi: 10.1200/JCO.22.01873
pubmed: 36493331
Zasadziński K, Spałek MJ, Rutkowski P (2022) Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—a Literature Review. Pharmaceutics 14(6):1204
doi: 10.3390/pharmaceutics14061204
pubmed: 35745777
pmcid: 9229675
Møller PK, Olling K, Berg M, Habæk I, Haislund B, Iversen AM et al (2018) Breast cancer patients report reduced sensitivity and pain using a barrier film during radiotherapy – A Danish intra-patient randomized multicentre study. Tech Innov Patient Support Radiat Oncol 7:20–25
doi: 10.1016/j.tipsro.2018.05.004
pubmed: 32095578
pmcid: 7033759
Herst PM, Bennett NC, Sutherland AE, Peszynski RI, Paterson DB, Jasperse ML (2014) Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Radiother Oncol 110(1):137–143
doi: 10.1016/j.radonc.2014.01.005
pubmed: 24486117
Wooding H, Yan J, Yuan L, Chyou TY, Gao S, Ward I et al (2018) The effect of Mepitel Film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study. Br J Radiol 91(1081):20170298
doi: 10.1259/bjr.20170298
pubmed: 29072852
Rades D, Narvaez CA, Splettstößer L, Dömer C, Setter C, Idel C et al (2019) A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). Radiother Oncol J Eur Soc Ther Radiol Oncol 139:79–82
doi: 10.1016/j.radonc.2019.07.023
Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. BMJ 18(343):d5928
doi: 10.1136/bmj.d5928
de Aguiar BRL, Guerra ENS, Normando AGC, Martins CC, Reis PEDD, Ferreira EB (2021) Effectiveness of photobiomodulation therapy in radiation dermatitis: A systematic review and meta-analysis. Crit Rev Oncol Hematol 162:103349
doi: 10.1016/j.critrevonc.2021.103349
pubmed: 33989768
de Menêses AG, Reis PEDD, Guerra ENS, Canto GDL, Ferreira EB (2018) Use of trolamine to prevent and treat acute radiation dermatitis: a systematic review and meta-analysis. Rev Lat Am Enfermagem 26:e2929
doi: 10.1590/1518-8345.2035.2929
pubmed: 29742271
pmcid: 5942864
Abstracts for MASCC/ISOO Annual Meeting (2022) Support Care Cancer 30(Suppl 1):1–207. https://doi.org/10.1007/s00520-022-07099-y