Lipid droplets control mitogenic lipid mediator production in human cancer cells.
Adipose triglyceride lipase
Cancer
Diacylglycerol acyltransferase
Lipid droplets
Lipid mediators
Phospholipase A(2)
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
30
03
2023
revised:
29
07
2023
accepted:
08
08
2023
medline:
11
9
2023
pubmed:
17
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids and precursors of oxygenated lipid mediators with diverse functions, including the control of cell growth, inflammation and tumourigenesis. However, the molecular pathways that control the availability of PUFAs for lipid mediator production are not well understood. Here, we investigated the crosstalk of three pathways in the provision of PUFAs for lipid mediator production: (i) secreted group X phospholipase A We combined lipidomic and functional analyses in cancer cell line models to dissect the trafficking of PUFAs between membrane phospholipids and LDs and determine the role of these pathways in lipid mediator production, cancer cell proliferation and tumour growth in vivo. We demonstrate that lipid mediator production strongly depends on TAG turnover. GX sPLA This study shifts the paradigm of PLA
Identifiants
pubmed: 37586657
pii: S2212-8778(23)00125-4
doi: 10.1016/j.molmet.2023.101791
pmc: PMC10470291
pii:
doi:
Substances chimiques
Group X Phospholipases A2
EC 3.1.1.4
Lipase
EC 3.1.1.3
Fatty Acids, Unsaturated
0
Phospholipids
0
Diacylglycerol O-Acyltransferase
EC 2.3.1.20
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101791Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.