Genome-wide association study on pharmacological outcomes of musculoskeletal pain in UK Biobank.
Journal
The pharmacogenomics journal
ISSN: 1473-1150
Titre abrégé: Pharmacogenomics J
Pays: United States
ID NLM: 101083949
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
19
07
2022
accepted:
07
08
2023
revised:
03
08
2023
medline:
22
11
2023
pubmed:
17
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
The pharmacological management of musculoskeletal pain starts with NSAIDs, followed by weak or strong opioids until the pain is under control. However, the treatment outcome is usually unsatisfying due to inter-individual differences. To investigate the genetic component of treatment outcome differences, we performed a genome-wide association study (GWAS) in ~23,000 participants with musculoskeletal pain from the UK Biobank. NSAID vs. opioid users were compared as a reflection of the treatment outcome of NSAIDs. We identified one genome-wide significant hit in chromosome 4 (rs549224715, P = 3.88 × 10
Identifiants
pubmed: 37587271
doi: 10.1038/s41397-023-00314-x
pii: 10.1038/s41397-023-00314-x
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Analgesics, Opioid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-168Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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