Persistent organic pollutants promote aggressiveness in prostate cancer.
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
15
09
2022
accepted:
18
07
2023
revised:
10
07
2023
medline:
18
9
2023
pubmed:
17
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Increasing evidence points towards a causal link between exposure to persistent organic pollutants (POPs) with increased incidence and aggressivity of various cancers. Among these POPs, dioxin and PCB-153 are widely found in our environment and represent a significant source of contamination. Dioxin exposure has already been linked to cancer such as non-Hodgkin's lymphoma, but remains to be more extensively investigated in other cancers. Potential implications of dioxin and PCB-153 in prostate cancer progression spurred us to challenge both ex vivo and in vivo models with low doses of these POPs. We found that dioxin or PCB-153 exposure increased hallmarks of growth and metastasis of prostate cancer cells ex vivo and in grafted NOD-SCID mice. Exposure induced histopathological carcinoma-like patterns in the Pten
Identifiants
pubmed: 37587334
doi: 10.1038/s41388-023-02788-2
pii: 10.1038/s41388-023-02788-2
doi:
Substances chimiques
2,4,5,2',4',5'-hexachlorobiphenyl
ZRU0C9E32O
Persistent Organic Pollutants
0
Dioxins
0
Polychlorinated Dibenzodioxins
0
Acetyltransferases
EC 2.3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2854-2867Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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