Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia.

Cell division cycle 42 (CDC42) Colitis Colorectal cancer (CRC) Inflammatory bowel diseases (IBD) Intestinal epithelial cell (IEC) Intestinal epithelial stem cell (IESC) Irradiation

Journal

Genes & diseases
ISSN: 2352-3042
Titre abrégé: Genes Dis
Pays: Netherlands
ID NLM: 101635967

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 16 09 2022
revised: 22 11 2022
accepted: 25 11 2022
medline: 17 8 2023
pubmed: 17 8 2023
entrez: 17 8 2023
Statut: epublish

Résumé

CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to determine the loss of intestinal

Identifiants

DOI: 10.1016/j.gendis.2022.11.024 PMID: 37588188 PMC: PMC10425749
pubmed: 37588188
doi: 10.1016/j.gendis.2022.11.024
pii: S2352-3042(22)00330-0
pmc: PMC10425749
doi:

Types de publication

Journal Article

Langues

eng

Pagination

413-429

Informations de copyright

© 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Déclaration de conflit d'intérêts

All authors have no conflicting financial or non-financial interests.

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Auteurs

Dongsheng Zhang (D)

Division of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer Center, Case Western Reserve University (CWRU), Cleveland, OH 44106, USA.
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.

Wenjuan Tang (W)

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Children's Hospital of Fudan University, Shanghai 201102, China.

Haitao Niu (H)

School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
Laboratory Animal Science (ILAS), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing 100006, China.

William Tse (W)

Division of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer Center, Case Western Reserve University (CWRU), Cleveland, OH 44106, USA.

Hai-Bin Ruan (HB)

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MI 55455, USA.

Helmut Dolznig (H)

Institute of Medical Genetics, Medical University of Vienna, Vienna 1040, Austria.

Thomas Knösel (T)

Institute of Pathology, Ludwig-Maximilians-University Munich, Munich 80539, Germany.

Friedrich Karl-Heinz (F)

Institute of Biochemistry II, University Hospital Jena, Jena 07743, Germany.

Madeleine Themanns (M)

Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna 1210, Austria.

Jiang Wang (J)

Department of Pathology, University of Cincinnati, Cincinnati, OH 45221, USA.

Mingquan Song (M)

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266005, China.

Lee Denson (L)

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.

Lukas Kenner (L)

Department of Pathology, Medical University of Vienna, Vienna 1040, Austria.

Richard Moriggl (R)

Ludwig Boltzmann Institute for Cancer Research, Vienna 1090, Austria.
Medical University of Vienna, Vienna 1040, Austria.
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna 1210, Austria.

Yi Zheng (Y)

Division of Experimental Hematology, CCHMC, Cincinnati, OH 45229, USA.

Xiaonan Han (X)

Division of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer Center, Case Western Reserve University (CWRU), Cleveland, OH 44106, USA.

Classifications MeSH