Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer's disease.

Alzheimer PET scan TSPO neuroinflammation neuropsychology

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2023
Historique:
received: 18 03 2023
accepted: 17 07 2023
medline: 17 8 2023
pubmed: 17 8 2023
entrez: 17 8 2023
Statut: epublish

Résumé

The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer's disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [

Identifiants

pubmed: 37588670
doi: 10.3389/fneur.2023.1189278
pmc: PMC10425281
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1189278

Informations de copyright

Copyright © 2023 Gouilly, Salabert, Bertrand, Goubeaud, Catala, Germain, Ainaoui, Rafiq, Benaiteau, Carlier, Nogueira, Planton, Hitzel, Méligne, Sarton, Silva, Lemesle, Payoux, Thalamas, Péran and Pariente.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Dominique Gouilly (D)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.

Anne-Sophie Salabert (AS)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Department of Nuclear Medicine, Toulouse Purpan University Hospital Center, Toulouse, France.

Elsa Bertrand (E)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Marie Goubeaud (M)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Hélène Catala (H)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Johanne Germain (J)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Nadéra Ainaoui (N)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Marie Rafiq (M)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Marie Benaiteau (M)

Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Jasmine Carlier (J)

Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Leonor Nogueira (L)

Laboratory of Cell Biology and Cytology, Toulouse Purpan University Hospital Center, Toulouse, France.

Mélanie Planton (M)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Anne Hitzel (A)

Department of Nuclear Medicine, Toulouse Purpan University Hospital Center, Toulouse, France.

Déborah Méligne (D)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.

Benjamine Sarton (B)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Critical Care Unit, Toulouse Purpan University Hospital Center, Toulouse, France.

Stein Silva (S)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Critical Care Unit, Toulouse Purpan University Hospital Center, Toulouse, France.

Béatrice Lemesle (B)

Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Pierre Payoux (P)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Department of Nuclear Medicine, Toulouse Purpan University Hospital Center, Toulouse, France.

Claire Thalamas (C)

Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.

Patrice Péran (P)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.

Jérémie Pariente (J)

Toulouse Neuroimaging Center, UMR 1214, Inserm/UPS, Toulouse, France.
Center of Clinical Investigation (CIC 1436), Toulouse Purpan University Hospital Center, Toulouse, France.
Department of Cognitive Neurology, Epilepsy and Movement Disorders, Toulouse Purpan University Hospital Center, Toulouse, France.

Classifications MeSH