Apolipoprotein E and viral infection: Risks and Mechanisms.
ApoE
COVID-19
HBV
HCV
HIV
HSV-1
MT: oligonucleotides: therapies and applications
SARS-CoV-2
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
12 Sep 2023
12 Sep 2023
Historique:
medline:
17
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
epublish
Résumé
Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and cholesterol homeostasis. In addition to being a well known genetic determinant of both neurodegenerative and cardiovascular diseases, ApoE is frequently involved in various viral infection-related diseases. Human ApoE protein is functionally polymorphic with three isoforms, namely, ApoE2, ApoE3, and ApoE4, with markedly altered protein structures and functions. ApoE4 is associated with increased susceptibility to infection with herpes simplex virus type-1 and HIV. Conversely, ApoE4 protects against hepatitis C virus and hepatitis B virus infection. With the outbreak of coronavirus disease 2019, ApoE4 has been shown to determine the incidence and progression of severe acute respiratory syndrome coronavirus 2 infection. These findings clearly indicate the critical role of ApoE in viral infection. Furthermore,
Identifiants
pubmed: 37588688
doi: 10.1016/j.omtn.2023.07.031
pii: S2162-2531(23)00204-4
pmc: PMC10425688
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
529-542Informations de copyright
© 2023.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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