The association of vitamin K status with lung function and disease in a general population.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
02
04
2023
accepted:
28
06
2023
medline:
17
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
epublish
Résumé
Matrix Gla protein (MGP) is an inhibitor of lung tissue calcification. The plasma level of dephosphorylated-uncarboxylated MGP (dp-ucMGP) is a biomarker of vitamin K status. The present study assessed whether lower vitamin K status (reflected by higher dp-ucMGP) was associated with lung function and lung disease/symptoms. A general population sample of 4092 individuals, aged 24 to 77 years, underwent a health examination including questionnaires, spirometry and measurements of plasma dp-ucMGP. Associations of dp-ucMGP with lung function and self-reported disease/symptoms were estimated using regression models adjusted for age, sex and height. Associations were expressed as β-estimates or odds ratios (ORs) per doubling in dp-ucMGP. Lower vitamin K status (higher dp-ucMGP) was associated with lower forced expiratory volume in 1 s (FEV Lower vitamin K status was associated with lower ventilatory capacity (lower FEV
Identifiants
pubmed: 37588689
doi: 10.1183/23120541.00208-2023
pii: 00208-2023
pmc: PMC10423920
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©The authors 2023.
Déclaration de conflit d'intérêts
Conflict of interest: F.B. Kampmann, A. Linneberg and S.M. Thysen have received an unrestricted grant and investigational products from Kappa Bioscience A/S for an intervention trial (The InterVitaminK Trial; clinicatrials.gov identifier NCT05259046) using vitamin K supplements as the active intervention. Conflict of interest: The other authors declare no other conflicts of interest.
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