Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial.
cognition
fitness
genetics
pediatrics
physical activity
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
pmc-release:
01
10
2024
medline:
25
9
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
ppublish
Résumé
We investigated the interaction between a genetic score and an exercise intervention on brain health in children with overweight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 yr, 59% girls) were randomized into a 20-wk combined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms [rs6265 (
Identifiants
pubmed: 37589055
doi: 10.1152/japplphysiol.00435.2023
pmc: PMC10642513
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Apolipoproteins E
0
Banques de données
figshare
['10.6084/m9.figshare.23884197']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
775-785Subventions
Organisme : NCATS NIH HHS
ID : U01 TR002004
Pays : United States
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