Optical coherence tomography angiography analysis of changes in the retina and the choroid after hemodialysis for end stage kidney disease.
ESKD
Hemodialysis
Imaging
OCTA
Vascular density
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
17 Aug 2023
17 Aug 2023
Historique:
received:
25
06
2023
accepted:
31
07
2023
medline:
17
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
aheadofprint
Résumé
To study effects of hemodialysis (HD) on retinal and choroidal vasculature in patients with end-stage kidney disease (ESKD) using optical coherence tomography angiography (OCTA). In this prospective study, we investigated eyes of patients undergoing hemodialysis for ESKD from Mondor University Hospital. Only one eye/patient was considered. Subfoveal choroidal thickness (SCT) was measured on enhanced-depth imaging optical coherence tomography (EDI-OCT) before and after the hemodialysis session. OCTA was used to extract retinal vascular density (superficial and deep capillary plexus, SCP, DCP) and choriocapillaris non-perfusion. Clinical, demographic and biological parameters (Blood B-Nitric Peptid rate prior to HD session) were reviewed. Twenty patients (mean age 53.2 ± 13.6 years, 10 males and 10 females) were included in this prospective study. SCT significantly decreased after the HD session (234.3 ± 56.14 µm before HD to 211.9 ± 60.79 µm after hemodialysis (Wilcoxon signed-rank test, p = 0.003)). Non-perfusion in the choriocapillaris significantly increased after HD (41.65 ± 3.58 before HD, 42.95 ± 3.19 after HD, p = 0.036) while no significant modification of the vascular density was observed in the retinal vasculature (SCP, DCP) around the macular zone or the optic nerve. An increased plasma B-Nitric Peptide (BNP) level prior to the onset of the HD session was significantly correlated with the decrease of the SCT (r = 0.45, p = 0.043). Hemodialysis in patients with ESKD is associated with a significant decrease in SCT and an increase in non-perfusion in the choriocapillaris on OCTA. A High BNP level prior to the onset of the hemodialysis appears to be correlated with the decrease in SCT.
Identifiants
pubmed: 37589862
doi: 10.1007/s10792-023-02847-3
pii: 10.1007/s10792-023-02847-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Singh AT, Mc Causland FR (2017) Osmolality and blood pressure stability during hemodialysis. Semin Dial 30(6):509–517. https://doi.org/10.1111/sdi.12629
doi: 10.1111/sdi.12629
pubmed: 28691402
pmcid: 5931915
Elbay A, Altinisik M, Dincyildiz A et al (2017) Are the effects of hemodialysis on ocular parameters similar during and after a hemodialysis session? Arq Bras Oftalmol 80(5):290–295. https://doi.org/10.5935/0004-2749.20170071
doi: 10.5935/0004-2749.20170071
pubmed: 29160538
Chen H, Zhang X, Shen X (2018) Ocular changes during hemodialysis in patients with end-stage renal disease. BMC Ophthalmol 18(1):208. https://doi.org/10.1186/s12886-018-0885-0
doi: 10.1186/s12886-018-0885-0
pubmed: 30139333
pmcid: 6107936
Chang IB, Lee JH, Kim JS (2017) Changes in choroidal thickness in and outside the macula after hemodialysis in patients with end-stage renal disease. Retina Phila Pa 37(5):896–905. https://doi.org/10.1097/IAE.0000000000001262
doi: 10.1097/IAE.0000000000001262
Nakano H, Hasebe H, Murakami K et al (2020) Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes. PLoS ONE 15(9):e0239072. https://doi.org/10.1371/journal.pone.0239072
doi: 10.1371/journal.pone.0239072
pubmed: 32915894
pmcid: 7485894
Ishibazawa A, Nagaoka T, Minami Y, Kitahara M, Yamashita T, Yoshida A (2015) Choroidal thickness evaluation before and after hemodialysis in patients with and without diabetes. Invest Ophthalmol Vis Sci 56(11):6534–6541. https://doi.org/10.1167/iovs.15-16719
doi: 10.1167/iovs.15-16719
pubmed: 26457539
Shin YU, Lee SE, Kang MH, Han SW, Yi JH, Cho H (2019) Evaluation of changes in choroidal thickness and the choroidal vascularity index after hemodialysis in patients with end-stage renal disease by using swept-source optical coherence tomography. Medicine (Baltimore) 98(18):e15421. https://doi.org/10.1097/MD.0000000000015421
doi: 10.1097/MD.0000000000015421
pubmed: 31045801
Coppolino G, Carnevali A, Gatti V et al (2021) OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study. Sci Rep 11(1):7202. https://doi.org/10.1038/s41598-021-86609-0
doi: 10.1038/s41598-021-86609-0
pubmed: 33785805
pmcid: 8009948
Shin YU, Lee DE, Kang MH et al (2018) Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis. Sci Rep 8(1):17184. https://doi.org/10.1038/s41598-018-35562-6
doi: 10.1038/s41598-018-35562-6
pubmed: 30464196
pmcid: 6249329
Jung JW, Chin HS, Lee DH, Yoon MH, Kim NR (2014) Changes in subfoveal choroidal thickness and choroidal extravascular density by spectral domain optical coherence tomography after haemodialysis: a pilot study. Br J Ophthalmol 98(2):207–212. https://doi.org/10.1136/bjophthalmol-2013-303645
doi: 10.1136/bjophthalmol-2013-303645
pubmed: 24187052
Yang SJ, Han YH, Song GI, Lee CH, Sohn SW (2013) Changes of choroidal thickness, intraocular pressure and other optical coherence tomographic parameters after haemodialysis. Clin Exp Optom 96(5):494–499. https://doi.org/10.1111/cxo.12056
doi: 10.1111/cxo.12056
pubmed: 23638771
Theodossiadis PG, Theodoropoulou S, Neamonitou G et al (2012) Hemodialysis-induced alterations in macular thickness measured by optical coherence tomography in diabetic patients with end-stage renal disease. Ophthalmol J Int Z Augenheilkd 227(2):90–94. https://doi.org/10.1159/000331321
doi: 10.1159/000331321
Kanbay M, Ertuglu LA, Afsar B et al (2020) An update review of intradialytic hypotension: concept, risk factors, clinical implications and management. Clin Kidney J 13(6):981–993. https://doi.org/10.1093/ckj/sfaa078
doi: 10.1093/ckj/sfaa078
pubmed: 33391741
pmcid: 7769545
Assayag M, Levy D, Seris P et al (2020) Relative change of protidemia level predicts intradialytic hypotension. J Am Heart Assoc 9(1):e014264. https://doi.org/10.1161/JAHA.119.014264
doi: 10.1161/JAHA.119.014264
pubmed: 31902281
pmcid: 6988166
Rubinger D, Backenroth R, Sapoznikov D (2013) Sympathetic nervous system function and dysfunction in chronic hemodialysis patients. Semin Dial 26(3):333–343. https://doi.org/10.1111/sdi.12093
doi: 10.1111/sdi.12093
pubmed: 23627490
Sander BP, Collins MJ, Read SA (2014) The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults. Exp Eye Res 128:181–189. https://doi.org/10.1016/j.exer.2014.10.003
doi: 10.1016/j.exer.2014.10.003
pubmed: 25304219
Robinson F, Riva CE, Grunwald JE, Petrig BL, Sinclair SH (1986) Retinal blood flow autoregulation in response to an acute increase in blood pressure. Invest Ophthalmol Vis Sci 27(5):722–726
pubmed: 3700021
Kur J, Newman EA, Chan-Ling T (2012) Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res 31(5):377–406. https://doi.org/10.1016/j.preteyeres.2012.04.004
doi: 10.1016/j.preteyeres.2012.04.004
pubmed: 22580107
pmcid: 3418965
Maisel AS, Krishnaswamy P, Nowak RM et al (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347:161–167. https://doi.org/10.1056/NEJMoa020233
doi: 10.1056/NEJMoa020233
pubmed: 12124404
Tani T, Nagaoka T, Nakabayashi S, Yoshioka T, Yoshida A (2014) Autoregulation of retinal blood flow in response to decreased ocular perfusion pressure in cats: comparison of the effects of increased intraocular pressure and systemic hypotension. Invest Ophthalmol Vis Sci 55(1):360–367. https://doi.org/10.1167/iovs.13-12591
doi: 10.1167/iovs.13-12591
pubmed: 24302588
Holmgaard K, Aalkjaer C, Lambert JDC, Hessellund A, Bek T (2008) The relaxing effect of perivascular tissue on porcine retinal arterioles in vitro is mimicked by N-methyl-D-aspartate and is blocked by prostaglandin synthesis inhibition. Acta Ophthalmol (Copenh) 86(1):26–33. https://doi.org/10.1111/j.1600-0420.2007.01010.x
doi: 10.1111/j.1600-0420.2007.01010.x