Yolk sac cell atlas reveals multiorgan functions during human early development.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 08 2023
18 08 2023
Historique:
medline:
21
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
ppublish
Résumé
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.
Identifiants
pubmed: 37590359
doi: 10.1126/science.add7564
pmc: PMC7614978
mid: EMS185071
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadd7564Subventions
Organisme : Wellcome Trust
ID : 215116
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206328
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R006237/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL151777
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107931
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211276
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107630
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220540
Pays : United Kingdom
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