DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in

Animals Caenorhabditis elegans / genetics Cell Cycle Proteins / metabolism Cryoelectron Microscopy DNA Replication Minichromosome Maintenance Proteins / chemistry Caenorhabditis elegans Proteins / chemistry Chromosomal Proteins, Non-Histone / genetics Protein Domains

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
22 09 2023
Historique:
medline: 25 9 2023
pubmed: 17 8 2023
entrez: 17 8 2023
Statut: ppublish

Résumé

Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that

Identifiants

DOI: 10.1126/science.adi4932 PMID: 37590372 PMC: PMC7615117
pubmed: 37590372
doi: 10.1126/science.adi4932
pmc: PMC7615117
mid: EMS187426
doi:

Substances chimiques

Cell Cycle Proteins 0
evl-18 protein, C elegans 0
Minichromosome Maintenance Proteins EC 3.6.4.12
Caenorhabditis elegans Proteins 0
Chromosomal Proteins, Non-Histone 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadi4932

Subventions

Organisme : Cancer Research UK
ID : 21782
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 24558
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1201/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12016/13
Pays : United Kingdom

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Auteurs

Yisui Xia (Y)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0002-5576-2147

Remi Sonneville (R)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.

Michael Jenkyn-Bedford (M)

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
ORCID: 0000-0003-2335-8278

Liqin Ji (L)

Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.

Constance Alabert (C)

Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.

Ye Hong (Y)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.
ORCID: 0009-0005-7980-6414

Joseph T P Yeeles (JTP)

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
ORCID: 0000-0002-2255-2119

Karim P M Labib (KPM)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0001-8861-379X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Protéines de maintenance des minichromosomes › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › DNSN-1 recruits GINS for CMG helicase assembly...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › DNSN-1 recruits GINS for CMG helicase assembly...