Roles for diacylglycerol in synaptic vesicle priming and release revealed by complete reconstitution of core protein machinery.
Munc13
Munc18
SNARE protein
neurotransmitter release
vesicle priming
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 08 2023
22 08 2023
Historique:
medline:
21
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
ppublish
Résumé
Here, we introduce the full functional reconstitution of genetically validated core protein machinery (SNAREs, Munc13, Munc18, Synaptotagmin, and Complexin) for synaptic vesicle priming and release in a geometry that enables detailed characterization of the fate of docked vesicles both before and after release is triggered with Ca
Identifiants
pubmed: 37590407
doi: 10.1073/pnas.2309516120
pmc: PMC10450444
doi:
Substances chimiques
Diglycerides
0
Synaptotagmins
134193-27-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2309516120Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK027044
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM141194
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK027044
Pays : United States
Commentaires et corrections
Type : UpdateOf
Références
Sci Adv. 2022 Jun 24;8(25):eabo5272
pubmed: 35731863
J Neurosci. 2005 Mar 9;25(10):2557-65
pubmed: 15758165
Neuron. 2007 Jul 5;55(1):11-24
pubmed: 17610814
Science. 2015 Sep 4;349(6252):1111-4
pubmed: 26339030
Curr Opin Struct Biol. 2019 Feb;54:179-188
pubmed: 30986753
Neuron. 2017 Aug 2;95(3):577-590.e5
pubmed: 28772122
J Biol Chem. 2014 Apr 4;289(14):9639-50
pubmed: 24532794
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2435-2442
pubmed: 30700546
Cell. 1998 Mar 20;92(6):759-72
pubmed: 9529252
Mol Biol Cell. 2009 Dec;20(23):4962-75
pubmed: 19812250
FEBS Lett. 2019 Jan;593(2):154-162
pubmed: 30570144
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):
pubmed: 33468652
Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2215124119
pubmed: 36454760
EMBO J. 2017 Mar 15;36(6):816-829
pubmed: 28137749
Small. 2022 Dec;18(51):e2205567
pubmed: 36328714
Nat Struct Mol Biol. 2013 Jun;20(6):679-86
pubmed: 23665582
Elife. 2022 Apr 20;11:
pubmed: 35442188
FEBS Lett. 2021 Feb;595(3):297-309
pubmed: 33222163
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5187-92
pubmed: 12700357
FEBS Lett. 2021 Sep;595(17):2185-2196
pubmed: 34227103
Neuron. 2002 Jan 31;33(3):397-409
pubmed: 11832227
Elife. 2015 Apr 02;4:
pubmed: 25831964
Nat Struct Mol Biol. 2011 Jul 24;18(8):941-6
pubmed: 21785413
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):
pubmed: 35135883
Langmuir. 2018 May 22;34(20):5849-5859
pubmed: 29694054
Elife. 2020 May 13;9:
pubmed: 32401194
Elife. 2017 Feb 08;6:
pubmed: 28177287
Elife. 2014 Aug 13;3:e03756
pubmed: 25122624
Annu Rev Biophys. 2015;44:339-67
pubmed: 26098518
Science. 2013 Jan 25;339(6118):421-5
pubmed: 23258414
Cell Mol Life Sci. 2015 Oct;72(20):3931-52
pubmed: 26153463
Nat Struct Mol Biol. 2015 Jul;22(7):547-54
pubmed: 26030875
Prog Lipid Res. 2010 Oct;49(4):429-37
pubmed: 20553968
Elife. 2019 Feb 28;8:
pubmed: 30816091
Science. 2009 Jan 23;323(5913):474-7
pubmed: 19164740
Elife. 2018 Dec 12;7:
pubmed: 30540253
Nat Commun. 2019 Jan 8;10(1):69
pubmed: 30622273
Biophys J. 1996 May;70(5):2299-306
pubmed: 9172753
J Neurosci. 2008 Aug 13;28(33):8257-67
pubmed: 18701688
FEBS Open Bio. 2022 Nov;12(11):1939-1957
pubmed: 35278279
Neuron. 2017 Aug 2;95(3):591-607.e10
pubmed: 28772123
Cell. 2002 Jan 11;108(1):121-33
pubmed: 11792326
Mol Biol Cell. 2008 Feb;19(2):722-34
pubmed: 18077557
Annu Rev Biochem. 2021 Jun 20;90:581-603
pubmed: 33823650
FEBS Lett. 2017 Nov;591(21):3459-3480
pubmed: 28983915
Nature. 1993 Mar 25;362(6418):318-24
pubmed: 8455717
Elife. 2017 May 06;6:
pubmed: 28477408
Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33
pubmed: 21785414
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13051-13056
pubmed: 27807132
Annu Rev Biophys Biomol Struct. 2002;31:151-75
pubmed: 11988466
Nat Struct Mol Biol. 2010 Mar;17(3):280-8
pubmed: 20154707
Biophys J. 2003 Oct;85(4):2351-62
pubmed: 14507699
J Neurosci. 2007 Jan 31;27(5):1200-10
pubmed: 17267576
Nature. 2000 Mar 23;404(6776):355-62
pubmed: 10746715
Nat Struct Mol Biol. 2005 Nov;12(11):1017-8
pubmed: 16228007
Elife. 2016 May 23;5:
pubmed: 27213521