Vancomycin Flushing Syndrome After the Use of Vancomycin-Impregnated Bone Graft During Spine Surgery: A Case Report.
Journal
JBJS case connector
ISSN: 2160-3251
Titre abrégé: JBJS Case Connect
Pays: United States
ID NLM: 101596828
Informations de publication
Date de publication:
01 07 2023
01 07 2023
Historique:
medline:
21
8
2023
pubmed:
17
8
2023
entrez:
17
8
2023
Statut:
epublish
Résumé
Intrawound vancomycin in spine surgery is a common clinical practice. We report a case of a 14-year-old adolescent girl undergoing surgery for scoliosis correction who developed features of vancomycin flushing syndrome after the use of vancomycin-impregnated bone graft. After resuscitation, she was extubated and had an uneventful postoperative recovery. At 1-year follow-up, she is back to her routine without any sequelae of the intraoperative event. The use of intrawound vancomycin can result in life-threatening reactions. With the increase in its use, the anesthetist and the surgeon must be aware of such complications.
Identifiants
pubmed: 37590562
doi: 10.2106/JBJS.CC.23.00181
pii: 01709767-202309000-00051
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 by The Journal of Bone and Joint Surgery, Incorporated.
Déclaration de conflit d'intérêts
Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSCC/C175).
Références
Aleem IS, Tan LA, Nassr A, Riew KD. Surgical site infection prevention following spine surgery. Glob Spine J. 2020;10(suppl 1):92S-98S.
Blumberg TJ, Woelber E, Bellabarba C, Bransford R, Spina N. Predictors of increased cost and length of stay in the treatment of postoperative spine surgical site infection. Spine J. 2018;18(2):300-6.
Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol. 1999;20(11):725-30.
Pull ter Gunne AF, Cohen DB. Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery. Spine (Phila Pa 1976). 2009;34(13):1422-8.
Blam OG, Vaccaro AR, Vanichkachorn JS, Albert TJ, Hilibrand AS, Minnich JM, Murphey SA. Risk factors for surgical site infection in the patient with spinal injury. Spine. 2003;28(13):1475-80.
Chen CE, Ko JY, Pan CC. Results of vancomycin-impregnated cancellous bone grafting for infected tibial nonunion. Arch Orthop Trauma Surg. 2005;125(6):369-75.
Chou PH, Lin HH, Yao YC, Chang MC, Liu CL, Wang ST. Does local vancomycin powder impregnated with autogenous bone graft and bone substitute decrease the risk of deep surgical site infection in degenerative lumbar spine fusion surgery?-An ambispective study. BMC Musculoskelet Disord. 2022;23(1):853.
Okafor R, Molinari W, Molinari R, Mesfin A. Intrawound vancomycin powder for spine tumor surgery. Glob Spine J. 2016;6(3):207-11.
Lemans JVC, Wijdicks SPJ, Boot W, Govaert GAM, Houwert RM, Öner FC, Kruyt MC. Intrawound treatment for prevention of surgical site infections in instrumented spinal surgery: a systematic comparative effectiveness review and meta-analysis. Glob Spine J. 2019;9(2):219-30.
Wazny LD, Daghigh B. Desensitization protocols for vancomycin hypersensitivity. Ann Pharmacother. 2001;35(11):1458-64.
Alvarez-Arango S, Ogunwole SM, Sequist TD, Burk CM, Blumenthal KG. Vancomycin infusion reaction - moving beyond “red man syndrome”. N Engl J Med. 2021;384(14):1283-6.
Bergeron L, Boucher FD. Possible red-man syndrome associated with systemic absorption of oral vancomycin in a child with normal renal function. Ann Pharmacother. 1994;28(5):581-4.
Wallace MR, Mascola JR, Oldfield EC. Red man syndrome: incidence, etiology, and prophylaxis. J Infect Dis. 1991;164(6):1180-5.
Polk RE, Healy DP, Schwartz LB, Rock DT, Garson ML, Roller K. Vancomycin and the red-man syndrome: pharmacodynamics of histamine release. J Infect Dis. 1988;157(3):502-7.
Francis A, Fatovich DM, Arendts G, Macdonald SP, Bosio E, Nagree Y, Mitenko HM, Brown SG. Serum mast cell tryptase measurements: sensitivity and specificity for a diagnosis of anaphylaxis in emergency department patients with shock or hypoxaemia. Emerg Med Australas. 2018;30(3):366-74.
Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes. Spine (Phila Pa 1976). 2011;36(24):2084-8.
O'Neill KR, Smith JG, Abtahi AM, Archer KR, Spengler DM, McGirt MJ, Devin CJ. Reduced surgical site infections in patients undergoing posterior spinal stabilization of traumatic injuries using vancomycin powder. Spine J. 2011;11(7):641-6.
Kerbel YE, Kirchner GJ, Sunkerneni AR, Lieber AM, Moretti VM, Khalsa AS, Levine MJ. The cost-effectiveness of vancomycin powder in lumbar laminectomy. Glob Spine J. 2021;11(1):28-33.
Sathish M, Girinivasan C. Is use of topical vancomycin in pediatric spine surgeries a safe option in the prevention of surgical site infections? A meta-analysis and systematic review of the literature. Glob Spine J. 2021;11(5):774-81.
DeFrancesco CJ, Flynn JM, Smith JT, Luhmann SJ, Sawyer JR, Glotzbecker M, Pahys J, Garg S, Vitale M, Farrington DM, Sturm P; Children’s Spine Study Group. Clinically apparent adverse reactions to intra-wound vancomycin powder in early onset scoliosis are rare. J Child Orthop. 2017;11(6):414-8.
Mariappan R, Manninen P, Massicotte EM, Bhatia A. Circulatory collapse after topical application of vancomycin powder during spine surgery. J Neurosurg Spine. 2013;19(3):381-3.
Chen CT, Ng KJ, Lin Y, Kao MC. Red man syndrome following the use of vancomycin-loaded bone cement in the primary total knee replacement: a case report. Medicine (Baltimore). 2018;97(51):e13371.
Zhang X, Zhai W, Li M, Guo X. Circulatory collapse during wound closure in spine surgery with an unknown cause: a possible adverse effect of topical application of vancomycin?. BMC Anesthesiol. 2021;21(1):4.
Nagahama Y, VanBeek MJ, Greenlee JDW. Red man syndrome caused by vancomycin powder. J Clin Neurosci. 2018;50:149-50.
Goh KL, Yusof NM, Ong CL. Allergic reaction following insertion of vancomycin loaded in bone cement. IIUM Med J Malaysia. 2014;13(1):61-64.
Taylor JS, Erkek E. Latex allergy: diagnosis and management. Dermatol Ther. 2004;17(4):289-301.
Vargas A, Foncea C, Astorga P. Latex allergy: Overview and recommendations for the perioperative management of high-risk patients. J Head Neck Spine Surg. 2017;1(1):555552.
Richter J, Zhou J, Pavlovic D, Scheibe R, Bac VH, Blumenthal J, Hung O, Murphy MF, Whynot S, Lehmann C. Vancomycin and to lesser extent tobramycin have vasomodulatory effects in experimental endotoxemia in the rat. Clin Hemorheol Microcirc. 2010;46(1):37-49.
Sahai J, Healy DP, Garris R, Berry A, Polk RE. Influence of antihistamine pretreatment on vancomycin-induced red-man syndrome. J Infect Dis. 1989;160(5):876-81.