Age as a modifier of the effects of sarcopenia on survival among colon cancer patients after surgery.
age
colon cancer
recurrence rate
sarcopenia
survival
visceral adiposity
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
06
07
2023
received:
17
05
2023
accepted:
16
07
2023
pubmed:
18
8
2023
medline:
18
8
2023
entrez:
18
8
2023
Statut:
ppublish
Résumé
Studies have been conducted to evaluate whether sarcopenia is a predictor for survival in patients with colon cancer postsurgery, but findings have been inconsistent, and effects of age were seldom evaluated. We recruited 133 patients with resectable colon cancer who underwent surgery between January 2014 and December 2017 at a teaching hospital to evaluate the effects of sarcopenia on survival, after adjusting for age and other potential predictors, including visceral adiposity (VA). Preoperative sarcopenia was associated with worse overall survival (OS: 62.3% vs. 83.8%, p = 0.04) and longer hospital stay (20.6 vs. 14.9 days, p < 0.01) while VA was not. Cox proportional hazards regressions showed that sarcopenia was associated with an adjusted hazard ratio (HR) of 2.91 (95% confidence interval [CI]: 1.08-7.86) after adjustment for other independent risk factors, but was not associated with disease free survival. In stratified analyses, we found that sarcopenia was an independent factor for worse OS (adjusted HR = 1.94; 95% CI: 1.11-3.38) among patients >70 years, but not among patients ≤70 years (HR = 0.48; 95% CI: 0.55-4.55). Age appeared to be a modifier of the effects of sarcopenia on OS among colon cancer patients postsurgery.
Sections du résumé
BACKGROUND
BACKGROUND
Studies have been conducted to evaluate whether sarcopenia is a predictor for survival in patients with colon cancer postsurgery, but findings have been inconsistent, and effects of age were seldom evaluated.
METHODS
METHODS
We recruited 133 patients with resectable colon cancer who underwent surgery between January 2014 and December 2017 at a teaching hospital to evaluate the effects of sarcopenia on survival, after adjusting for age and other potential predictors, including visceral adiposity (VA).
RESULTS
RESULTS
Preoperative sarcopenia was associated with worse overall survival (OS: 62.3% vs. 83.8%, p = 0.04) and longer hospital stay (20.6 vs. 14.9 days, p < 0.01) while VA was not. Cox proportional hazards regressions showed that sarcopenia was associated with an adjusted hazard ratio (HR) of 2.91 (95% confidence interval [CI]: 1.08-7.86) after adjustment for other independent risk factors, but was not associated with disease free survival. In stratified analyses, we found that sarcopenia was an independent factor for worse OS (adjusted HR = 1.94; 95% CI: 1.11-3.38) among patients >70 years, but not among patients ≤70 years (HR = 0.48; 95% CI: 0.55-4.55).
CONCLUSIONS
CONCLUSIONS
Age appeared to be a modifier of the effects of sarcopenia on OS among colon cancer patients postsurgery.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1121-1132Subventions
Organisme : Chi Mei Medical Center, Chi Mei Hospital, Liouying, and Kaohsiung Medical University Research Foundation
ID : 112CM-KMU-01(X112001)
Organisme : Chi Mei Medical Center, Chi Mei Hospital, Liouying, and Kaohsiung Medical University Research Foundation
ID : CLFHR11113
Informations de copyright
© 2023 Wiley Periodicals LLC.
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