Dysregulation of adipokines levels among healthy first-degree relatives of type 2 diabetes patients.
Adipokines
Adiponectin
Family history
Insulin resistance
Leptin
Type 2 diabetes mellitus
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
16
10
2022
revised:
29
07
2023
accepted:
01
08
2023
medline:
18
8
2023
pubmed:
18
8
2023
entrez:
18
8
2023
Statut:
epublish
Résumé
Leptin, adiponectin and its ratio (L/A), as well as adipocyte fatty acid binding protein (A-FABP) have shown association to type 2 diabetes and atherosclerosis. Since first degree relatives (FDR) of type 2 diabetes are known to have higher risks of developing aforementioned diseases, this study aimed to see differences in adipokines profiles between FDR of type 2 diabetes and non-FDR counterpart. Age, sex and body mass index (BMI)-matched normotensive-normoglycemic subjects, aged 19-39 years with BMI<30 kg/m Of 116 subjects recruited, there were significant difference of insulin level (6.00 vs 5.00 μIU/mL, The FDR status was independently associated with adiponectin level. Furthermore, higher L/A ratio was more pronounced in non-obese FDR than those of non-FDR subjects, suggesting that FDR status may already contribute to the development of adipokines dysregulation before obesity occurs.
Sections du résumé
Background
UNASSIGNED
Leptin, adiponectin and its ratio (L/A), as well as adipocyte fatty acid binding protein (A-FABP) have shown association to type 2 diabetes and atherosclerosis. Since first degree relatives (FDR) of type 2 diabetes are known to have higher risks of developing aforementioned diseases, this study aimed to see differences in adipokines profiles between FDR of type 2 diabetes and non-FDR counterpart.
Methods
UNASSIGNED
Age, sex and body mass index (BMI)-matched normotensive-normoglycemic subjects, aged 19-39 years with BMI<30 kg/m
Results
UNASSIGNED
Of 116 subjects recruited, there were significant difference of insulin level (6.00 vs 5.00 μIU/mL,
Conclusion
UNASSIGNED
The FDR status was independently associated with adiponectin level. Furthermore, higher L/A ratio was more pronounced in non-obese FDR than those of non-FDR subjects, suggesting that FDR status may already contribute to the development of adipokines dysregulation before obesity occurs.
Identifiants
pubmed: 37593625
doi: 10.1016/j.heliyon.2023.e18887
pii: S2405-8440(23)06095-4
pmc: PMC10428054
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e18887Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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