Calcineurin B inhibits calcium oxalate crystallization, growth and aggregation via its high calcium-affinity property.
Calcineurin inhibitor
Cyclosporin
EF-hand
FK506
Kidney stone
Stone inhibitor
Tacrolimus
Urolithiasis
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
05
2023
revised:
30
07
2023
accepted:
30
07
2023
medline:
18
8
2023
pubmed:
18
8
2023
entrez:
18
8
2023
Statut:
epublish
Résumé
Calcineurin inhibitors (CNIs) are widely used in organ transplantation to suppress immunity and prevent allograft rejection. However, some transplant patients receiving CNIs have hypocitraturia, hyperoxaluria and kidney stone with unclear mechanism. We hypothesized that CNIs suppress activities of urinary calcineurin, which may serve as the stone inhibitor. This study aimed to investigate effects of calcineurin B (CNB) on calcium oxalate monohydrate (COM) stone formation. Sequence and structural analyses revealed that CNB contained four EF-hand (Ca
Identifiants
pubmed: 37593722
doi: 10.1016/j.csbj.2023.07.038
pii: S2001-0370(23)00273-8
pmc: PMC10427926
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3854-3864Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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