Antimicrobial efficacy of a nitric oxide-releasing ampicillin conjugate catheter lock solution on clinically-isolated antibiotic-resistant bacteria.


Journal

Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571

Informations de publication

Date de publication:
26 Sep 2023
Historique:
pmc-release: 26 09 2024
medline: 4 10 2023
pubmed: 18 8 2023
entrez: 18 8 2023
Statut: epublish

Résumé

Antibiotic lock therapy (ALT) is standard clinical practice for treating bacteremia linked with catheter-related bloodstream infections (CRBSIs). However, this strategy frequently fails against multi-drug-resistant bacteria in clinical settings. In this study, a novel approach to utilize a nitric oxide (NO) donor

Identifiants

pubmed: 37594048
doi: 10.1039/d3bm00775h
pmc: PMC10529818
mid: NIHMS1927029
doi:

Substances chimiques

Anti-Bacterial Agents 0
Nitric Oxide 31C4KY9ESH
Ampicillin 7C782967RD
Anti-Infective Agents 0
Nitric Oxide Donors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6561-6572

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL134899
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151473
Pays : United States

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Auteurs

Manjyot Kaur Chug (MK)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

Lauren Griffin (L)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

Mark Garren (M)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

Emma Tharp (E)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

Grace H Nguyen (GH)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

Hitesh Handa (H)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.
Pharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA, 30602, USA.

Elizabeth J Brisbois (EJ)

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.

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Classifications MeSH