Quality assurance of postharvest grapes against Botrytis cinerea by terbinafine.
Antifungal activity
Botrytis cinerea
Cell membrane
Grape preservation
Terbinafine
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
18 Aug 2023
18 Aug 2023
Historique:
received:
03
07
2023
accepted:
07
08
2023
medline:
18
8
2023
pubmed:
18
8
2023
entrez:
18
8
2023
Statut:
epublish
Résumé
Worldwide, fruit is an indispensable treasure house of nutrition for human beings, occupying a vital position of human diet. Postharvest fruit storage requires efficient antifungal agents to control Botrytis cinerea, which is a vital postharvest disease affecting fruit and leading to enormous losses. However, with the enormous abuse of existing antifungal drugs, the problem of drug-resistant fungi is imminent, making the controlling diseases caused by pathogenic fungi even more challenging. Drug repurposing is an efficient alternative method, we evaluated a well-known antifungal chemical, terbinafine, against the agricultural pathogen, B. cinerea in vitro, as a result, terbinafine showed strong antifungal activity. Furthermore, the in vivo antifungal activity of terbinafine was evaluated, the results showed that terbinafine could reduce the decay area on grapes. Terbinafine could disrupt the cell membrane integrity, increase cell membrane permeability, and eventual cell death of B. cinerea. In addition, terbinafine reduced decay incidence, and weight loss and maintained the soluble solids, titratable acidity, ascorbic acid, total phenolic, and malondialdehyde content during the storage period of grapes. Overall, terbinafine could be an antifungal preservative for postharvest table grapes fresh-keeping.
Identifiants
pubmed: 37594518
doi: 10.1007/s13659-023-00389-w
pii: 10.1007/s13659-023-00389-w
pmc: PMC10439064
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Subventions
Organisme : High-level Talent Promotion and Training Project of Kunming
ID : 2022SCP003
Organisme : Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform
ID : 2022YKZY001
Organisme : Scientific and Technological Innovation Team of Yunnan Province
ID : 202105AE160006
Informations de copyright
© 2023. Kunming Institute of Botany, CAS.
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