A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota-Fat Axis and Inhibiting the Hepatic TLR4/NF-κB Signaling Pathway.
a newly synbiotic combination
energy metabolism
gut microbiota
inflammatory response
intestinal permeability
lipopolysaccharides
obesity
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
18 Aug 2023
18 Aug 2023
Historique:
revised:
11
06
2023
received:
14
03
2023
medline:
18
8
2023
pubmed:
18
8
2023
entrez:
18
8
2023
Statut:
aheadofprint
Résumé
Obesity has been recognized as a worldwide public health crisis, this is accompanied by dysregulation of the intestinal microbiota and upregulation of liver steatosis and adipose inflammation. Synbiotic as a novel alternative therapy for obesity have recently gained much attention. This study innovatively research the anti-obesity properties of a newly synbiotic composed of Lactobacillus acidophilus, Bifidobacterium infantis and konjac glucomannan oligosaccharides. The synbiotic treatment can reduce body weight, fat mass, blood sugar, liver steatosis and adipose inflammation in obesity mice fed by high-fat diet (HFD). Meanwhile, synbiotic treatment activated brown adipose tissue and improve energy, glucose and lipid metabolism. In addition, synbiotic treatment not solely enhanced the protection of intestinal barrier, but also ameliorated gut microbiota dysbiosis directly by enhancing beneficial microbes and reducing potentially harmful bacteria. Furthermore, the microbiome phenotype and functional prediction showed that synbiotic treatment can improve the gut microbiota functions involving inflammatory state, immune response, metabolism and pathopoiesia. The synbiotic may be an effective candidate treatment strategy for the clinical prevention and treatment of obesity and other associated metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver diseases by alleviating inflammatory response, regulating energy metabolism and maintaining the balance of intestinal microecology.
Identifiants
pubmed: 37594720
doi: 10.1002/mnfr.202300141
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300141Subventions
Organisme : Shanxi Scholarship Council of China
ID : 2020-079
Organisme : Shanxi Province Natural Science Foundation
ID : 201901D 111194
Organisme : Shanxi Province Natural Science Foundation
ID : 202203021221182
Organisme : Science Research Start-up Fund for Doctor of Shanxi Medical University
ID : XD1807
Organisme : Science Research Start-up Fund for Doctor of Shanxi Province
ID : SD1807
Organisme : Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi
ID : 2019L0425
Organisme : Shanxi Province Science Foundation for Youths
ID : 201901D211314
Organisme : Shanxi Province Science Foundation for Youths
ID : 202103021223240
Informations de copyright
© 2023 Wiley-VCH GmbH.
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