Implementation of Brachytherapy for Patients With Cervical Cancer in Ethiopia: A 3-Year Practice Report.
Journal
JCO global oncology
ISSN: 2687-8941
Titre abrégé: JCO Glob Oncol
Pays: United States
ID NLM: 101760170
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
medline:
21
8
2023
pubmed:
18
8
2023
entrez:
18
8
2023
Statut:
ppublish
Résumé
Although cervical cancer is the second most commonly diagnosed cancer in Ethiopia, brachytherapy (BT) was not a component in patient treatment until 2015. The purpose of this study was to identify the patterns of utilization as well as to describe the practice of BT in Ethiopia. A retrospective descriptive data analysis of 138 patients with cervical cancer treated with a curative potential using BT from 2015 to 2018 at Tikur Anbassa Specialized Hospital, which housed the only BT facility in Ethiopia during the study period. During the first 3-year period of BT service commencement, each year n = 37, n = 36, and n = 65 patients with cervical cancer were treated, respectively, with curative intention treatment. The median age of these 138 patients was 50 years (range, 22-75). All the patients were in International Federation of Gynecology and Obstetrics stage Ib-IIIb group, and stage IIb (66.4%) was the predominant. Majority (79%) of the patients were treated primarily with radiotherapy (RT), while 21% received RT after surgery. More than half of these patients (62%) received a total RT dose of 82 Gy in equivalent dose in 2 Gy fractions (EQD2), while the rest received a dose ranging from 76 to 86 Gy. Concurrent cisplatin with RT was given only for 36% of the patients for undocumented reasons. The overall treatment time including both external-beam RT and BT was greater than 8 weeks in 21% of the patients. The utilization of BT service increased gradually and BT enabled the delivery of a higher RT dose to patients with cervical cancer (mostly stage IIB). However, there was protracted treatment duration and low concurrent chemotherapy utilization.
Identifiants
pubmed: 37595167
doi: 10.1200/GO.22.00407
pmc: PMC10581656
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200407Références
J Clin Oncol. 2008 Dec 10;26(35):5802-12
pubmed: 19001332
Brachytherapy. 2017 Jan - Feb;16(1):133-140
pubmed: 27836496
Int J Radiat Oncol Biol Phys. 1993 Dec 1;27(5):1051-6
pubmed: 8262826
Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):756-64
pubmed: 18191335
Int J Radiat Oncol Biol Phys. 1999 Jul 1;44(4):855-66
pubmed: 10386643
Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):201-210
pubmed: 29619965
Cochrane Database Syst Rev. 2010 Jan 20;(1):CD008285
pubmed: 20091664
Int J Gynaecol Obstet. 2019 Apr;145(1):129-135
pubmed: 30656645
Int J Gynecol Cancer. 2010 Aug;20(6):1074-8
pubmed: 20683420
JAMA. 2020 Oct 20;324(15):1532-1542
pubmed: 33079153
Oncologist. 2014 Jul;19(7):727-34
pubmed: 24951611
Int J Radiat Oncol Biol Phys. 1995 Jul 30;32(5):1275-88
pubmed: 7635767
N Engl J Med. 1999 Apr 15;340(15):1198-200
pubmed: 10202172
JCO Glob Oncol. 2021 Feb;7:173-182
pubmed: 33529076
Semin Radiat Oncol. 2010 Apr;20(2):121-9
pubmed: 20219550
J Glob Oncol. 2019 Nov;5:1-8
pubmed: 31834831
Semin Radiat Oncol. 2017 Apr;27(2):184-188
pubmed: 28325246