An ethical framework for human embryology with embryo models.
blastoids
definition
embryo
embryo models
embryology
ethics
gastruloids
human
legal
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
17 08 2023
17 08 2023
Historique:
received:
28
01
2023
revised:
24
04
2023
accepted:
18
07
2023
medline:
21
8
2023
pubmed:
19
8
2023
entrez:
18
8
2023
Statut:
ppublish
Résumé
A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest "tipping points" for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.
Identifiants
pubmed: 37595564
pii: S0092-8674(23)00807-3
doi: 10.1016/j.cell.2023.07.028
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3548-3557Subventions
Organisme : Cancer Research UK
ID : CC2186
Pays : United Kingdom
Organisme : Medical Research Council
ID : CC2186
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2186
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V005367/2
Pays : United Kingdom
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests N.C.R. is an inventor on the patents “Blastoid, cell line based artificial blastocyst” (EP2986711) and “Blastocyst-like cell aggregate and methods” (EP21151455.9) that are both licensed to dawn-bio, a company he co-founded. A.M.A. and N.M. are inventors on the patents "Polarised three-dimensional cellular aggregates” (PCT/GB2019/052668) and “human polarised three-dimensional cellular” (PCT/GB2019/052670), maintained by Cambridge Enterprise.