Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.

Asthma asthma-COPD overlap chronic obstructive pulmonary disease heterogeneity polygenic risk scores

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 11 01 2023
revised: 27 07 2023
accepted: 08 08 2023
pubmed: 19 8 2023
medline: 19 8 2023
entrez: 18 8 2023
Statut: ppublish

Résumé

Asthma and chronic obstructive pulmonary disease (COPD) have distinct and overlapping genetic and clinical features. We sought to test the hypothesis that polygenic risk scores (PRSs) for asthma (PRS We developed and tested 2 asthma PRSs and applied the higher performing PRS In meta-analyses of 102,477 participants, the PRS PRSs for asthma and spirometry are both associated with ACO and asthma exacerbations. Genetic prediction performance differs in research versus electronic health record-based cohorts.

Sections du résumé

BACKGROUND BACKGROUND
Asthma and chronic obstructive pulmonary disease (COPD) have distinct and overlapping genetic and clinical features.
OBJECTIVE OBJECTIVE
We sought to test the hypothesis that polygenic risk scores (PRSs) for asthma (PRS
METHODS METHODS
We developed and tested 2 asthma PRSs and applied the higher performing PRS
RESULTS RESULTS
In meta-analyses of 102,477 participants, the PRS
CONCLUSIONS CONCLUSIONS
PRSs for asthma and spirometry are both associated with ACO and asthma exacerbations. Genetic prediction performance differs in research versus electronic health record-based cohorts.

Identifiants

DOI: 10.1016/j.jaci.2023.08.002 PMID: 37595761
pubmed: 37595761
pii: S0091-6749(23)00988-0
doi: 10.1016/j.jaci.2023.08.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1423-1432

Subventions

Organisme : NHLBI NIH HHS
ID : K23 HL136851
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135142
Pays : United States

Informations de copyright

Published by Elsevier Inc.

Auteurs

Matthew Moll (M)

Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass.

Joanne E Sordillo (JE)

Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass.

Auyon J Ghosh (AJ)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, SUNY Upstate Medical Center, Syracuse, NY.

Lystra P Hayden (LP)

Department of Pediatrics, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Gregory McDermott (G)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Mass.

Michael J McGeachie (MJ)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Amber Dahlin (A)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Anshul Tiwari (A)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Monica G Manmadkar (MG)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Eric D Abston (ED)

Department of Thoracic Surgery, Massachusetts General Hospital, Boston, Mass.

Chandan Pavuluri (C)

Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass.

Aabida Saferali (A)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Sofina Begum (S)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

John P Ziniti (JP)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Amund Gulsvik (A)

Department of Clinical Science, University of Bergen, Bergen, Norway.

Per S Bakke (PS)

Department of Clinical Science, University of Bergen, Bergen, Norway.

Hugues Aschard (H)

Department of Computational Biology, Institut Pasteur, Universit de Paris, Paris, France.

Carlos Iribarren (C)

Division of Research, Kaiser Permanente Northern California, Oakland, Calif.

Craig P Hersh (CP)

Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass.

Jeffrey A Sparks (JA)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Mass.

Brian D Hobbs (BD)

Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass.

Jessica A Lasky-Su (JA)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Edwin K Silverman (EK)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Scott T Weiss (ST)

Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass.

Ann Chen Wu (AC)

Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass.

Michael H Cho (MH)

Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass. Electronic address: remol@channing.harvard.edu.

Classifications MeSH