Activity of the Substantia Nigra Pars Reticulata during Saccade Adaptation.
adaptation
learning
monkey
saccade
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
20
03
2023
revised:
14
08
2023
accepted:
15
08
2023
medline:
15
9
2023
pubmed:
19
8
2023
entrez:
18
8
2023
Statut:
epublish
Résumé
When movements become inaccurate, the resultant error induces motor adaptation to improve accuracy. This error-based motor learning is regarded as a cerebellar function. However, the influence of the other brain areas on adaptation is poorly understood. During saccade adaptation, a type of error-based motor learning, the superior colliculus (SC) sends a postsaccadic error signal to the cerebellum to drive adaptation. Since the SC is directly inhibited by the substantia nigra pars reticulata (SNr), we hypothesized that the SNr might influence saccade adaptation by affecting the SC error signal. In fact, previous studies indicated that the SNr encodes motivation and motivation influences saccade adaptation. In this study, we first established that the SNr projects to the rostral SC, where small error signals are generated, in nonhuman primates. Then, we examined SNr activity while the animal underwent adaptation. SNr neurons paused their activity in association with the error. This pause was shallower and delayed compared with those of no-error trial saccades. The pause at the end of the adaptation was shallower and delayed compared with that at the beginning of the adaptation. The change in the intertrial interval, an indicator of motivation, and adaptation speed had a positive correlation with the changes in the error-related pause. These results suggest that (1) the SNr exhibits a unique activity pattern during the error interval; (2) SNr activity increases during adaptation, consistent with the decrease in SC activity; and (3) motivational decay during the adaptation session might increase SNr activity and influence the adaptation speed.
Identifiants
pubmed: 37596048
pii: ENEURO.0092-23.2023
doi: 10.1523/ENEURO.0092-23.2023
pmc: PMC10500979
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY023277
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY033760
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY001730
Pays : United States
Informations de copyright
Copyright © 2023 Kojima et al.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
Références
Neuroscience. 2017 Jul 4;355:113-125
pubmed: 28499971
Exp Brain Res. 1986;65(1):200-12
pubmed: 2433144
J Neurosci. 2006 Jul 19;26(29):7741-55
pubmed: 16855102
eNeuro. 2021 Apr 2;8(2):
pubmed: 33707204
J Appl Physiol. 1966 May;21(3):1068-70
pubmed: 4958032
Physiol Rev. 2000 Jul;80(3):953-78
pubmed: 10893428
J Neurophysiol. 1999 Dec;82(6):3458-75
pubmed: 10601475
Sci Rep. 2017 Aug 29;7(1):9566
pubmed: 28852092
Proc Natl Acad Sci U S A. 2008 May 20;105(20):7309-14
pubmed: 18477700
J Neurosci. 2010 Oct 20;30(42):14235-44
pubmed: 20962244
J Neurophysiol. 2003 Aug;90(2):1235-44
pubmed: 12711711
Prog Neurobiol. 2004 Jan;72(1):27-53
pubmed: 15019175
J Neurosci. 2009 Apr 22;29(16):5266-75
pubmed: 19386923
J Neurophysiol. 2002 Jun;87(6):2778-89
pubmed: 12037180
Eur J Neurosci. 2005 Jul;22(2):448-64
pubmed: 16045498
Brain Res. 1980 May 19;190(1):39-50
pubmed: 6769538
Neuroscience. 1984 Sep;13(1):61-76
pubmed: 6387531
J Neurosci. 2010 Mar 10;30(10):3715-27
pubmed: 20220005
Vis Neurosci. 1998 Sep-Oct;15(5):903-22
pubmed: 9764533
Prog Brain Res. 2008;171:153-9
pubmed: 18718294
J Comp Neurol. 1992 Jan 1;315(1):98-116
pubmed: 1371782
J Neurophysiol. 2007 Jun;97(6):4129-42
pubmed: 17392414
J Neurophysiol. 2007 Jun;97(6):4096-107
pubmed: 17442764
J Neurophysiol. 1997 Feb;77(2):874-95
pubmed: 9065856
Exp Brain Res. 1991;87(2):389-401
pubmed: 1722761
Vision Res. 2008 Sep;48(20):2070-89
pubmed: 18513781
J Neurophysiol. 2005 Sep;94(3):1707-26
pubmed: 16105954
Curr Biol. 2005 Dec 20;15(24):2179-89
pubmed: 16360681
Vision Res. 1972 Nov;12(11):1795-808
pubmed: 4627952
J Neurosci. 2002 Mar 1;22(5):1883-94
pubmed: 11880518
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8987-E8995
pubmed: 30185563
J Neurophysiol. 1983 May;49(5):1230-53
pubmed: 6864248
Brain Res Bull. 1997;43(5):473-83
pubmed: 9250621
J Neurophysiol. 2015 Jul;114(1):125-37
pubmed: 25855693
J Neurosci. 2012 Nov 21;32(47):16917-32
pubmed: 23175843
Brain. 2002 Jul;125(Pt 7):1570-82
pubmed: 12077006
J Comp Neurol. 1987 Nov 8;265(2):224-41
pubmed: 3320110
J Neurophysiol. 2002 Feb;87(2):679-95
pubmed: 11826037
J Neurophysiol. 1985 Jan;53(1):292-308
pubmed: 2983038
J Comp Neurol. 1977 Jun 1;173(3):583-612
pubmed: 404340
J Fr Ophtalmol. 2012 Apr;35(4):242-50
pubmed: 22018708
J Neurophysiol. 2008 Oct;100(4):1949-66
pubmed: 18650308
J Neurosci. 2009 Dec 2;29(48):15213-22
pubmed: 19955374
Neuroscience. 1982 Oct;7(10):2377-88
pubmed: 7177379
Philos Trans R Soc Lond B Biol Sci. 2011 Feb 27;366(1564):492-503
pubmed: 21242138
Vision Res. 1980;20(6):535-8
pubmed: 6776685
J Neurophysiol. 1995 Jun;73(6):2313-33
pubmed: 7666141
Exp Brain Res. 2002 Feb;142(4):439-62
pubmed: 11845241
Brain Res Bull. 1983 Apr;10(4):529-37
pubmed: 6305462
Exp Brain Res. 1994;100(2):293-306
pubmed: 7813666
Brain Res. 1977 Oct 21;135(1):147-52
pubmed: 410480
Front Neurol. 2017 Nov 09;8:592
pubmed: 29170650