Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development.
GABA
adolescent
axon initial segment
chandelier
prefrontal pyramidal
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
13 09 2023
13 09 2023
Historique:
received:
01
04
2023
revised:
04
07
2023
accepted:
01
08
2023
pmc-release:
13
03
2024
medline:
15
9
2023
pubmed:
19
8
2023
entrez:
18
8
2023
Statut:
ppublish
Résumé
Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials (APs) to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS), a region between the soma and axon proper that is also the site of action potential (AP) generation. This polarization between dendrites and axons extends to inhibitory neurotransmission. In adulthood, the neurotransmitter GABA hyperpolarizes dendrites but instead depolarizes axons. These differences in function collide at the AIS. Multiple studies have shown that GABAergic signaling in this region can share properties of either the mature axon or mature dendrite, and that these properties evolve over a protracted period encompassing periadolescent development. Here, we explored how developmental changes in GABAergic signaling affect AP initiation. We show that GABA at the axon initial segment inhibits action potential initiation in layer (L)2/3 pyramidal neurons in prefrontal cortex from mice of either sex across GABA reversal potentials observed in periadolescence. These actions occur largely through current shunts generated by GABA
Identifiants
pubmed: 37596053
pii: JNEUROSCI.0605-23.2023
doi: 10.1523/JNEUROSCI.0605-23.2023
pmc: PMC10500977
doi:
Substances chimiques
Chlorides
0
Receptors, GABA-A
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6357-6368Informations de copyright
Copyright © 2023 the authors.
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